Foslevodopa
Vyalev (foslevodopa) is a small molecule pharmaceutical. Foslevodopa was first approved as Vyalev on 2024-10-16. It is used to treat parkinson disease in the USA.
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Vyalev
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vyalev | New Drug Application | 2024-10-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
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Clinical Trials
10 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | — | 4 | — | 3 | 10 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Foslevodopa |
| INN | foslevodopa |
| Description | Foslevodopa is an L-tyrosine derivative that is L-dopa in which the hydroxy group at position 4' is replaced by a phosphonooxy group. It is a water-soluble prodrug of levodopa which is used for the treatment of Parkinson's disease. It has a role as an antiparkinson drug and a prodrug. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and an O-phosphoamino acid. It is functionally related to a L-dopa. |
| Classification | Small molecule |
| Drug class | dopamine receptor agonists; phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1ccc(OP(=O)(O)O)c(O)c1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 97321-87-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4594379 |
| ChEBI ID | — |
| PubChem CID | 127766 |
| DrugBank | DB16683 |
| UNII ID | 37NQZ0J76I (ChemIDplus, GSRS) |
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12 adverse events reported
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