Foscarbidopa
Vyalev (foscarbidopa) is a small molecule pharmaceutical. Foscarbidopa was first approved as Vyalev on 2024-10-16. It is used to treat parkinson disease in the USA.
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Commercial
Therapeutic Areas
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Trade Name
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Combinations
Vyalev
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vyalev | New Drug Application | 2024-10-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
Agency Specific
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Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | — | 4 | — | 2 | 8 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Foscarbidopa |
| INN | foscarbidopa |
| Description | Foscarbidopa is an L-tyrosine derivative that is carbidopa in which the hydroxy group at position 4' is replaced by a phosphonooxy group. It is a water-soluble prodrug of carbidopa which is used for the treatment of Parkinson's disease. It has a role as a prodrug and an antiparkinson drug. It is an O-phosphoamino acid, a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid. It is functionally related to a carbidopa (anhydrous). |
| Classification | Small molecule |
| Drug class | dopamine receptor agonists; phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@](Cc1ccc(OP(=O)(O)O)c(O)c1)(NN)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 1907685-81-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4802240 |
| ChEBI ID | — |
| PubChem CID | 121288738 |
| DrugBank | DB16171 |
| UNII ID | 5NT8HCA4OO (ChemIDplus, GSRS) |
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Safety
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12 adverse events reported
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