Emend, Ivemend(fosaprepitant)
Emend, Focinvez, Ivemend (fosaprepitant) is a small molecule pharmaceutical. Fosaprepitant was first approved as Ivemend on 2008-01-11. It has been approved in Europe to treat neoplasms and vomiting. It is known to target substance-P receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Emend, Focinvez (generic drugs available since 2016-06-09)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosaprepitant dimeglumine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EMEND | Merck Sharp & Dohme | N-022023 RX | 2010-11-12 | 1 products, RLD, RS |
| FOCINVEZ | SteriScience | N-216686 RX | 2023-08-22 | 1 products, RLD, RS |
| FOSAPREPITANT DIMEGLUMINE | Teva | N-210064 RX | 2019-09-05 | 1 products |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| focinvez | New Drug Application | 2023-08-31 |
| fosaprepitant | ANDA | 2024-01-18 |
| fosaprepitant dimeglumine | ANDA | 2023-12-04 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
FOSAPREPITANT DIMEGLUMINE, EMEND, MERCK AND CO INC | |||
| 2025-05-02 | D-186 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Fosaprepitant Dimeglumine, Focinvez, Steriscience | |||
| 11065265 | 2039-01-11 | DP | |
ATC Codes
No data
Clinical
Clinical Trials
169 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | 7 | 20 | 17 | 9 | 12 | 64 |
| Nausea | D009325 | HP_0002018 | R11.0 | 2 | 10 | 6 | 5 | 6 | 29 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | 2 | 2 | 3 | 11 | 5 | 22 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | 4 | 2 | 4 | 13 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 4 | 1 | 1 | 7 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | 1 | 3 | 5 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | 1 | 3 | 4 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 1 | — | 3 |
| Leukemia | D007938 | — | C95 | — | — | — | 1 | 2 | 3 |
| Pruritus | D011537 | HP_0000989 | L29 | — | 2 | — | 1 | — | 3 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 9 | — | — | 9 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 2 | 1 | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | 1 | — | 1 | 4 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | — | 1 | — | 2 | 3 |
| Nasopharyngeal neoplasms | D009303 | — | — | 1 | — | 1 | — | — | 2 |
| Female genital neoplasms | D005833 | — | — | — | — | 2 | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | — | — | 1 | — | — | 1 |
| Digestive system surgical procedures | D013505 | — | — | — | — | 1 | — | — | 1 |
| Testicular neoplasms | D013736 | — | C62 | — | — | 1 | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | — | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 3 | — | — | — | 3 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | 2 | — | — | — | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | 2 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | 1 | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | — | 1 |
| Drug therapy | D004358 | — | — | — | 1 | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | — | — | — | — | 2 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 1 | — | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | — | — | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Heroin dependence | D006556 | EFO_0004240 | — | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | — | — | — | 1 | 1 |
| Sarcoma | D012509 | — | — | — | — | — | — | 1 | 1 |
| Brenner tumor | D001948 | — | — | — | — | — | — | 1 | 1 |
| Endometrioid carcinoma | D018269 | — | — | — | — | — | — | 1 | 1 |
| Fallopian tube neoplasms | D005185 | — | — | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fosaprepitant |
| INN | fosaprepitant |
| Description | Fosaprepitant, sold under the brand names Emend (US) and Ivemend (EU) among others, is an antiemetic medication, administered intravenously. It is a prodrug of aprepitant.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O[C@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 172673-20-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1199324 |
| ChEBI ID | 64321 |
| PubChem CID | 219090 |
| DrugBank | DB06717 |
| UNII ID | 6L8OF9XRDC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TACR1
TACR1
Organism
Homo sapiens
Gene name
TACR1
Gene synonyms
NK1R, TAC1R
NCBI Gene ID
Protein name
substance-P receptor
Protein synonyms
neurokinin receptor 1, NK-1 receptor, NK-1R, Tachykinin receptor 1, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Uniprot ID
Mouse ortholog
Tacr1 (21336)
substance-P receptor (Q8BYR7)
Variants
No data
Financial
Revenue by drug
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Emend – Merck Sharp & Dohme
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Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 592 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,219 adverse events reported
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