Arixtra(fondaparinux)
Arixtra, Fondaparinux (fondaparinux) is an oligosaccharide pharmaceutical. Fondaparinux was first approved as Arixtra on 2001-12-07. It is used to treat pulmonary embolism and venous thrombosis in the USA. It has been approved in Europe to treat myocardial infarction, pulmonary embolism, unstable angina, and venous thrombosis. The pharmaceutical is active against antithrombin-III.
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Arixtra, Fondaparinux
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| arixtra | New Drug Application | 2024-12-10 |
| fondaparinux sodium | ANDA | 2024-11-05 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| venous thrombosis | — | D020246 | I82.40 |
| pulmonary embolism | EFO_0003827 | D011655 | I26 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1652 | Injection, fondaparinux sodium, 0.5 mg |
Clinical
Clinical Trials
94 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thromboembolism | D013923 | — | — | — | 1 | 10 | 1 | 4 | 15 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 1 | 4 | 1 | 3 | 8 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 1 | 1 | 1 | 1 | 2 | 6 |
| Embolism | D004617 | — | — | 1 | 1 | 1 | 1 | 2 | 6 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 2 | 1 | 1 | 4 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | 2 | 1 | 4 |
| Syndrome | D013577 | — | — | — | — | 1 | 1 | — | 2 |
| Critical illness | D016638 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombosis | D013927 | — | — | 1 | 1 | 5 | — | 5 | 12 |
| Venous thrombosis | D020246 | — | I82.40 | 1 | 1 | 5 | — | 5 | 12 |
| Knee prosthesis | D007720 | — | — | — | — | 1 | — | — | 1 |
| Knee injuries | D007718 | — | — | — | — | 1 | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | — | 1 |
| Thrombophlebitis | D013924 | — | — | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ataxia | D001259 | — | R27.0 | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fondaparinux |
| INN | fondaparinux sodium |
| Description | Fondaparinux (trade name Arixtra) is an anticoagulant medication chemically related to low molecular weight heparins. It is marketed by Viatris. A generic version developed by Alchemia is marketed within the US by Dr. Reddy's Laboratories.
|
| Classification | Oligosaccharide |
| Drug class | antihrombotic indirect selective synthetic factor Xa inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO[C@H]1O[C@H](COS(=O)(=O)O)[C@@H](O[C@@H]2O[C@@H](C(=O)O)[C@@H](O[C@H]3O[C@H](COS(=O)(=O)O)[C@@H](O[C@@H]4O[C@H](C(=O)O)[C@@H](O[C@H]5O[C@H](COS(=O)(=O)O)[C@@H](O)[C@H](O)[C@H]5NS(=O)(=O)O)[C@H](O)[C@H]4O)[C@H](OS(=O)(=O)O)[C@H]3NS(=O)(=O)O)[C@H](O)[C@H]2OS(=O)(=O)O)[C@H](O)[C@H]1NS(=O)(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 104993-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201202 |
| ChEBI ID | 61033 |
| PubChem CID | 636380 |
| DrugBank | DB00569 |
| UNII ID | X0Q6N9USOZ (ChemIDplus, GSRS) |
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Estimated US medical usage
Fondaparinux
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,850 documents
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Safety
Black-box Warning
Black-box warning for: Arixtra, Fondaparinux sodium
Adverse Events
Top Adverse Reactions
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8,479 adverse events reported
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