Fluoxetine
Fluoxetine, Prozac (fluoxetine) is a small molecule pharmaceutical. Fluoxetine was first approved as Prozac on 1987-12-29. It is used to treat bulimia, major depressive disorder, obsessive-compulsive disorder, and panic disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter. In addition, it is known to target anoctamin-1, voltage-gated potassium channel KCNC1, G protein-activated inward rectifier potassium channel 2, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2B, equilibrative nucleoside transporter 4, 5-hydroxytryptamine receptor 2A, and 5-hydroxytryptamine receptor 2C.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
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YTD
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2Y
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Results first post date
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Commercial
Trade Name
FDA
EMA
Fluoxetine, Sarafem (discontinued: Fluoxetine, Prozac, Sarafem, Selfemra)
Combinations
Olanzapine fluoxetine (discontinued: Symbyax)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluoxetine hydrochloride
Tradename
Company
Number
Date
Products
PROZACEli LillyN-018936 RX1987-12-29
3 products, RLD
FLUOXETINE HYDROCHLORIDETWi PharmaceuticalsN-202133 RX2011-10-06
1 products, RLD, RS
Show 6 discontinued
Fluoxetine hydrochloride
+
Olanzapine
Tradename
Company
Number
Date
Products
SYMBYAXEli LillyN-021520 DISCN2003-12-24
5 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
fluoxetineANDA2025-03-17
fluoxetine hclANDA2025-01-22
fluoxetine hydrochlorideANDA2025-03-06
gaboxetineunapproved drug other2011-08-01
olanzapine and fluoxetineANDA2024-04-19
prozacNew Drug Application2024-11-13
sentraflox am-10unapproved drug other2011-08-17
sentroxatineunapproved drug other2011-08-01
symbyaxNew Drug Application2025-01-22
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N06: Psychoanaleptics
N06A: Antidepressants
N06AB: Selective serotonin reuptake inhibitors
N06AB03: Fluoxetine
N06C: Psycholeptics and psychoanaleptics in combination
N06CA: Antidepressants in combination with psycholeptics
N06CA03: Fluoxetine and psycholeptics
HCPCS
No data
Clinical
Clinical Trials
369 clinical trials
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Indications Phases 3
Indications Phases 2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C80268
Type 1 diabetes mellitusD003922EFO_0001359E10224
HypoglycemiaD007003E16.2134
Cognitive dysfunctionD060825G31.84123
Pure autonomic failureD054970112
MalnutritionD044342EFO_0008572E40-E4622
Body weightD001835EFO_000433811
Weight lossD01543111
Brain neoplasmsD001932EFO_0003833C7111
GliomaD005910EFO_000052011
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug-related side effects and adverse reactionsD064420T88.744
Taste disordersD01365133
Generalized anxiety disorderD00009864733
Drug interactionsD00434722
Chronic painD05935022
Suicidal ideationD059020EFO_0004320R45.85122
Hot flashesD01958422
Cardiac surgical proceduresD00634822
Orthopedic proceduresD01963722
Magnetic resonance imagingD00827922
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFluoxetine
INNfluoxetine
Description
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine is an aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group. It is a member of (trifluoromethyl)benzenes, an aromatic ether and a secondary amino compound.
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Classification
Small molecule
Drug classantidepressants (fluoxetine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1
Identifiers
PDB
CAS-ID54910-89-3
RxCUI
ChEMBL IDCHEMBL41
ChEBI ID86990
PubChem CID3386
DrugBankDB00472
UNII ID01K63SUP8D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
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Uniprot ID
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Fluoxetine
Total medical expenditures per year (USD, in millions)
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Price per prescription (USD)
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Fluoxetine
+
Olanzapine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 45,572 documents
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Safety
Black-box Warning
Black-box warning for: Fluoxetine, Fluoxetine hcl, Fluoxetine hydrochloride, Gaboxetine, Olanzapine and fluoxetine, Prozac, Sentraflox am-10, Sentroxatine, Symbyax
Adverse Events
Top Adverse Reactions
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48,587 adverse events reported
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