Flecainide
Flecainide (flecainide) is a small molecule pharmaceutical. Flecainide was first approved as Tambocor on 1985-10-31. It is used to treat atrial fibrillation, cardiac arrhythmias, supraventricular tachycardia, and ventricular tachycardia in the USA. It is known to target potassium voltage-gated channel subfamily A member 1, potassium voltage-gated channel subfamily A member 5, potassium voltage-gated channel subfamily A member 2, voltage-gated potassium channel KCNC1, and potassium voltage-gated channel subfamily A member 7.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Flecainide (discontinued: Flecainide, Tambocor)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| flecainide acetate | ANDA | 2024-10-16 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
66 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 3 | 9 | 14 | 20 | 45 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | 1 | 4 | 1 | 3 | 9 |
| Tachycardia | D013610 | HP_0001649 | R00.0 | — | — | 2 | 3 | 3 | 8 |
| Ventricular tachycardia | D017180 | — | I47.2 | — | 1 | 1 | 3 | 1 | 6 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 2 | — | 1 | 1 | 4 |
| Ventricular premature complexes | D018879 | — | I49.3 | — | 1 | — | 2 | 1 | 4 |
| Brugada syndrome | D053840 | Orphanet_130 | I49.8 | — | — | — | 1 | 2 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Supraventricular tachycardia | D013617 | HP_0004755 | I47.1 | — | — | 1 | — | 2 | 3 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 2 | — | — | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 2 | — | — | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | 1 | 2 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | 1 | 2 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | — | 1 | — | 1 | 2 |
| Coronary disease | D003327 | — | — | — | — | 2 | — | — | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | — | — | 2 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 2 | — | — | 2 |
| Ischemic stroke | D000083242 | — | — | — | — | 2 | — | — | 2 |
Show 9 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 1 | — | — | 2 | 3 |
| Arrhythmogenic right ventricular dysplasia | D019571 | Orphanet_247 | I42.8 | — | 1 | — | — | 1 | 2 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | — | — | 1 | 2 |
| Premature cardiac complexes | D005117 | — | I49.40 | — | 1 | — | — | 1 | 2 |
| Sleepiness | D000077260 | — | R40.0 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
| Disorders of excessive somnolence | D006970 | — | G47.1 | — | 1 | — | — | — | 1 |
| Narcolepsy | D009290 | HP_0030050 | G47.4 | — | 1 | — | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep deprivation | D012892 | — | F51.12 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Flecainide |
| INN | flecainide |
| Description | Flecainide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It is a monocarboxylic acid amide, a member of piperidines, an organofluorine compound and an aromatic ether. It is a conjugate base of a flecainide(1+). |
| Classification | Small molecule |
| Drug class | Ic antiarrhythmic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 54143-55-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL652 |
| ChEBI ID | 75984 |
| PubChem CID | 3356 |
| DrugBank | DB01195 |
| UNII ID | K94FTS1806 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Flecainide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,766 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,111 adverse events reported
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