Finafloxacin
Xtoro (finafloxacin) is a small molecule pharmaceutical. Finafloxacin was first approved as Xtoro on 2014-12-17. It is used to treat otitis externa and staphylococcal infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| otorhinolaryngologic diseases | D010038 |
Trade Name
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 2 | — | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | — | 2 |
| Communicable diseases | D003141 | — | — | 1 | 1 | — | — | — | 2 |
| Helicobacter infections | D016481 | EFO_1000961 | — | 1 | 1 | — | — | — | 2 |
| Bacterial infections | D001424 | — | A49 | — | 1 | — | — | — | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | 1 | — | — | — | 1 |
| Gram-negative bacterial infections | D016905 | — | — | — | 1 | — | — | — | 1 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Finafloxacin |
| INN | finafloxacin |
| Description | Finafloxacin is a quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, 7 and 8 by cyclopropyl, fluoro, hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl and cyano groups respectively; an antibiotic used for treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. It has a role as an antimicrobial agent and an antibacterial drug. It is a quinolone, a monocarboxylic acid, an organofluorine compound, a secondary amino compound, a tertiary amino compound, a nitrile and a member of cyclopropanes. |
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#Cc1c(N2C[C@@H]3NCCO[C@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12 |
Identifiers
| PDB | — |
| CAS-ID | 209342-40-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1908370 |
| ChEBI ID | 85176 |
| PubChem CID | 11567473 |
| DrugBank | — |
| UNII ID | D26OSN9Q4R (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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