Ficlatuzumab
Ficlatuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target hepatocyte growth factor.
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FDA approval date
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Study first post date
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Start date
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Completion date
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Commercial
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | — | 1 | — | — | 3 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | 1 | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | 1 | — | — | 2 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | — | — | — | 2 |
| Respiratory tract neoplasms | D012142 | EFO_0003853 | D14 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 1 | 1 |
| Mullerian mixed tumor | D018200 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ficlatuzumab |
| INN | ficlatuzumab |
| Description | Ficlatuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743018 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 77E89833TG (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HGF
HGF
Organism
Homo sapiens
Gene name
HGF
Gene synonyms
HPTA
NCBI Gene ID
Protein name
hepatocyte growth factor
Protein synonyms
fibroblast-derived tumor cytotoxic factor, hepatocyte growth factor (hepapoietin A; scatter factor), Hepatopoietin-A, lung fibroblast-derived mitogen, Scatter factor, SF
Uniprot ID
Mouse ortholog
Hgf (15234)
hepatocyte growth factor (Q6LBE6)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 329 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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