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AboutPricing
Drug ReportsFexofenadine
Fexofenadine
Allegr, Allegra, Fexofenadine (fexofenadine) is a small molecule pharmaceutical. Fexofenadine was first approved as Allegra on 1996-07-25. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Allegra, Fexofenadine (discontinued: Allegra, Fexofenadine)
Combinations
Allegr, Fexofenadine pseudoephedrine (discontinued: Fexofenadine pseudoephedrine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fexofenadine hydrochloride
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ALLEGRA-D 12 HOUR ALLERGY AND CONGESTIONSanofiN-020786 OTC2011-01-24
1 products, RLD, RS
ALLEGRA-D 24 HOUR ALLERGY AND CONGESTIONSanofiN-021704 OTC2011-01-24
1 products, RLD, RS
Fexofenadine hydrochloride
Tradename
Company
Number
Date
Products
ALLEGRA ALLERGYSanofiN-020872 OTC2011-01-24
1 products, RLD
ALLEGRA HIVESSanofiN-020872 OTC2011-01-24
1 products, RLD, RS
ALLEGRA ALLERGYSanofiN-020872 OTC2011-01-24
1 products, RLD, RS
CHILDREN'S ALLEGRA ALLERGYSanofiN-201373 OTC2011-01-24
1 products, RLD, RS
Show 8 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
12hr allergy reliefANDA2021-09-24
24hr allergy reliefANDA2025-06-12
allegra allergyNew Drug Application2025-02-19
allegra allergy 24 hourC2002632025-02-11
allegra allergy allegra allergy, travel basixNew Drug Application2024-11-19
allegra allergy childrens allegra allergyNew Drug Application2014-03-24
allegra d 12 hour allergy and congestionNew Drug Application2014-03-19
allegra d-12 hourNew Drug Application2009-12-08
allegra hives 24hrNew Drug Application2024-11-18
allegra--d 24 hourNew Drug Application2012-09-25
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
sinusitisEFO_0007486D012852J32
asthmaEFO_0000270D001249J45
common coldEFO_0007214D003139J00
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Fexofenadine Hydrochloride, Children'S Allegra Allergy, Chattem Sanofi
89330972030-08-02DP
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AX: Other antihistamines for systemic use in atc
— R06AX26: Fexofenadine
HCPCS
No data
Clinical
Clinical Trials
106 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Allergic rhinitisD065631—J30.9—139—12
RhinitisD012220EFO_0008521J31—139—12
Allergic rhinitis seasonalD006255EFO_0003956J30——22—4
Allergic rhinitis perennialD012221EFO_1001417J30.89—111—2
HypersensitivityD006967EFO_0003785T78.40———1—1
Fabry diseaseD000795Orphanet_324E75.21———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J45——3——3
Atopic dermatitisD003876EFO_0000274L20—11——1
EczemaD004485—L30.9—11——1
DermatitisD003872—L30.9—11——1
PruritusD011537—L29——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFexofenadine
INNfexofenadine
Description
Fexofenadine is a piperidine-based anti-histamine compound. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is a member of piperidines and a tertiary amine. It is functionally related to an isobutyric acid.
Classification
Small molecule
Drug classAntihistamine; H1 receptor antagonist
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Identifiers
PDB—
CAS-ID83799-24-0
RxCUI—
ChEMBL IDCHEMBL914
ChEBI ID5050
PubChem CID3348
DrugBankDB00950
UNII IDE6582LOH6V (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Fexofenadine
Total medical expenditures per year (USD, in millions)
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Fexofenadine
+
Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,050 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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31,332 adverse events reported
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