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AboutPricing
Drug ReportsFexofenadine
Fexofenadine
Allegr, Allegra, Fexofenadine (fexofenadine) is a small molecule pharmaceutical. Fexofenadine was first approved as Allegra on 1996-07-25. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Allegra, Fexofenadine (discontinued: Allegra, Fexofenadine)
Combinations
Allegr, Fexofenadine pseudoephedrine (discontinued: Fexofenadine pseudoephedrine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fexofenadine hydrochloride
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ALLEGRA-D 12 HOUR ALLERGY AND CONGESTIONSanofiN-020786 OTC2011-01-24
1 products, RLD, RS
ALLEGRA-D 24 HOUR ALLERGY AND CONGESTIONSanofiN-021704 OTC2011-01-24
1 products, RLD, RS
Fexofenadine hydrochloride
Tradename
Company
Number
Date
Products
ALLEGRA ALLERGYSanofiN-020872 OTC2011-01-24
1 products, RLD
ALLEGRA HIVESSanofiN-020872 OTC2011-01-24
1 products, RLD, RS
ALLEGRA ALLERGYSanofiN-020872 OTC2011-01-24
1 products, RLD, RS
CHILDREN'S ALLEGRA ALLERGYSanofiN-201373 OTC2011-01-24
1 products, RLD, RS
Show 8 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
12hr allergy and congestion reliefANDA2024-10-29
12hr allergy reliefANDA2021-09-24
24hr allergy reliefANDA2021-06-15
allegra allergyNew Drug Application2025-02-19
allegra allergy 24 hourC2002632025-02-11
allegra allergy allegra allergy, travel basixNew Drug Application2024-11-19
allegra allergy childrens allegra allergyNew Drug Application2014-03-24
allegra d 12 hour allergy and congestionNew Drug Application2014-03-19
allegra d-12 hourNew Drug Application2009-12-08
allegra hives 24hrNew Drug Application2024-11-18
Show 44 more
Agency Specific
FDA
EMA
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Patent Expiration
Patent
Expires
Flag
FDA Information
Fexofenadine Hydrochloride, Children'S Allegra Allergy, Chattem Sanofi
89330972030-08-02DP
ATC Codes
R: Respiratory system drugs
R06: Antihistamines for systemic use
R06A: Antihistamines for systemic use
R06AX: Other antihistamines for systemic use in atc
R06AX26: Fexofenadine
HCPCS
No data
Clinical
Clinical Trials
105 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients22
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFexofenadine
INNfexofenadine
Description
Fexofenadine is a piperidine-based anti-histamine compound. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is a member of piperidines and a tertiary amine. It is functionally related to an isobutyric acid.
Classification
Small molecule
Drug classAntihistamine; H1 receptor antagonist
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Identifiers
PDB
CAS-ID83799-24-0
RxCUI
ChEMBL IDCHEMBL914
ChEBI ID5050
PubChem CID3348
DrugBankDB00950
UNII IDE6582LOH6V (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Fexofenadine
Total medical expenditures per year (USD, in millions)
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Fexofenadine
+
Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,377 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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30,542 adverse events reported
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