Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Fenretinide |
INN | fenretinide |
Description | 4-hydroxyphenyl retinamide is a retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. It has a role as an antineoplastic agent and an antioxidant. It is a retinoid and a monocarboxylic acid amide. It is functionally related to an all-trans-retinoic acid. |
Classification | Small molecule |
Drug class | retinol derivatives |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1 |
PDB | — |
CAS-ID | 65646-68-6 |
RxCUI | — |
ChEMBL ID | CHEMBL7301 |
ChEBI ID | 42588 |
PubChem CID | 5288209 |
DrugBank | DB05076 |
UNII ID | 187EJ7QEXL (ChemIDplus, GSRS) |