Fenoprofen
Fenoprofen (fenoprofen) is a small molecule pharmaceutical. Fenoprofen was first approved as Nalfon on 1982-01-01. It is used to treat osteoarthritis, pain, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 1. In addition, it is known to target sodium-coupled monocarboxylate transporter 1.
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Commercial
Trade Name
FDA
EMA
Fenoprofen (discontinued: Fenoprofen, Nalfon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fenoprofen calcium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NALFON | Dista Products | N-017710 DISCN | 1982-01-01 | 1 products, RLD |
| NALFON | Key Therapeutics | N-017604 DISCN | 1982-01-01 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| fenoprofen | New Drug Application | 2017-04-21 |
| fenoprofen calcium | ANDA | 2024-10-01 |
| nalfon | ANDA | 2024-07-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
| pain | EFO_0003843 | D010146 | R52 |
| osteoarthritis | EFO_0002506 | D010003 | M15-M19 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fenoprofen |
| INN | fenoprofen |
| Description | Fenoprofen is a monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. It has a role as a non-steroidal anti-inflammatory drug, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an antipyretic, a non-narcotic analgesic and a drug allergen. It is a conjugate acid of a fenoprofen(1-). |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1cccc(Oc2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 31879-05-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1297 |
| ChEBI ID | 5004 |
| PubChem CID | 3342 |
| DrugBank | DB00573 |
| UNII ID | RA33EAC7KY (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS1
Gene synonyms
COX1
NCBI Gene ID
Protein name
prostaglandin G/H synthase 1
Protein synonyms
COX-1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs1 (19224)
prostaglandin G/H synthase 1 (P22437)
Alternate
SLC5A8
SLC5A8
Organism
Homo sapiens
Gene name
SLC5A8
Gene synonyms
AIT, SMCT, SMCT1
NCBI Gene ID
Protein name
sodium-coupled monocarboxylate transporter 1
Protein synonyms
Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, solute carrier family 5 (iodide transporter), member 8, solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8, Solute carrier family 5 member 8
Uniprot ID
Mouse ortholog
Slc5a8 (216225)
sodium-coupled monocarboxylate transporter 1 (Q8VD01)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Fenoprofen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,031 documents
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Safety
Black-box Warning
Black-box warning for: Fenoprofen, Fenoprofen calcium, Nalfon
Adverse Events
Top Adverse Reactions
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50 adverse events reported
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