Felbamate
Felbamate, Felbatol (felbamate) is a small molecule pharmaceutical. Felbamate was first approved as Felbatol on 1993-07-29. It is used to treat complex partial epilepsy, epilepsy, lennox gastaut syndrome, and seizures in the USA.
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Commercial
Therapeutic Areas
Trade Name
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Felbamate, Felbatol (discontinued: Felbamate)
Indications
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Agency Specific
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | 2 | 3 |
| Intellectual disability | D008607 | EFO_0003847 | F73 | — | — | — | 1 | — | 1 |
| Drug resistant epilepsy | D000069279 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | 1 | — | — | — | 1 |
| Gliosarcoma | D018316 | — | — | 1 | 1 | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | 1 | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Financial stress | D000086522 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Felbamate |
| INN | felbamate |
| Description | Felbamate is the bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy. It has a role as an anticonvulsant and a neuroprotective agent. |
| Classification | Small molecule |
| Drug class | tranquilizers/antiepileptics (propanediol and pentanediol groups) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)OCC(COC(N)=O)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 25451-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1094 |
| ChEBI ID | 4995 |
| PubChem CID | 3331 |
| DrugBank | DB00949 |
| UNII ID | X72RBB02N8 (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Felbamate
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Safety
Black-box Warning
Black-box warning for: Felbamate, Felbatol
Adverse Events
Top Adverse Reactions
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674 adverse events reported
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