Famotidine
/ Famotidine /, Famotidine, Famotidine /, Pepcid (famotidine) is a small molecule pharmaceutical. Famotidine was first approved as Pepcid on 1986-10-15. It is used to treat duodenal ulcer, dyspepsia, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against histamine H2 receptor.
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Commercial
Trade Name
FDA
EMA
Famotidine, Pepcid ac (discontinued: Famotidine, Fluxid, Pepcid, Pepcid ac, Pepcid rpd)
CombinationsFamotidine, carbonate, magnesium hydroxide, Ibuprofen famotidine, Pepcid complete (discontinued: Duexis, Famotidine, carbonate, magnesium hydroxide, Ibuprofen famotidine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Famotidine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PEPCID AC | Johnson & Johnson | N-020325 OTC | 1995-04-28 | 2 products, RLD |
| PEPCID AC | Johnson & Johnson | N-020801 OTC | 2007-12-17 | 1 products, RLD, RS |
| FAMOTIDINE | Sagent Pharmaceuticals | N-219935 RX | 2025-07-16 | 3 products, RLD, RS |
Show 9 discontinued
Calcium carbonate
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Famotidine
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Magnesium hydroxide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PEPCID COMPLETE | Johnson & Johnson | N-020958 OTC | 2000-10-16 | 1 products, RLD, RS |
Famotidine
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Ibuprofen
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUEXIS | Horizon Therapeutics Public | N-022519 DISCN | 2011-04-23 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acid controller | ANDA | 2025-08-13 |
| acid reducer | ANDA | 2025-07-17 |
| acid reducer complete | ANDA | 2025-07-15 |
| acid reducer plus antacid | ANDA | 2025-08-11 |
| acid relief | ANDA | 2025-03-27 |
| amazon basic care acid reducer | ANDA | 2025-04-22 |
| basic care acid reducer | ANDA | 2025-02-10 |
| basic care dual action complete | ANDA | 2022-07-11 |
| basic care famotidine | ANDA | 2020-02-19 |
| basic care heartburn prevention | ANDA | 2023-01-01 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| S0028 | Injection, famotidine, 20 mg |
Clinical
Clinical Trials
8022 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Sclerosis | D012598 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Famotidine |
| INN | famotidine |
| Description | Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour.
|
| Classification | Small molecule |
| Drug class | H2-receptor antagonists (cimetidine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(N)=Nc1nc(CSCC/C(N)=N/S(N)(=O)=O)cs1 |
Identifiers
| PDB | — |
| CAS-ID | 76824-35-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL902 |
| ChEBI ID | 4975 |
| PubChem CID | 5702160 |
| DrugBank | DB00927 |
| UNII ID | 5QZO15J2Z8 (ChemIDplus, GSRS) |
Target
Variants
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Financial
Revenue by drug
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Duexis – Horizon Therapeutics Public
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Tabular view
Estimated US medical usage
Famotidine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Famotidine
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Ibuprofen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,993 documents
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Safety
Black-box Warning
Black-box warning for: Duexis, Ibuprofen and famotidine
Adverse Events
Top Adverse Reactions
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14,723 adverse events reported
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