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AboutPricing
Drug ReportsFamotidine
Famotidine
/ Famotidine /, Famotidine, Famotidine /, Pepcid (famotidine) is a small molecule pharmaceutical. Famotidine was first approved as Pepcid on 1986-10-15. It is used to treat duodenal ulcer, dyspepsia, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against histamine H2 receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Famotidine, Pepcid ac (discontinued: Famotidine, Fluxid, Pepcid, Pepcid ac, Pepcid rpd)
Combinations
Famotidine, carbonate, magnesium hydroxide, Ibuprofen famotidine, Pepcid complete (discontinued: Duexis, Famotidine, carbonate, magnesium hydroxide, Ibuprofen famotidine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Famotidine
Tradename
Company
Number
Date
Products
PEPCID ACJohnson & JohnsonN-020325 OTC1995-04-28
2 products, RLD
PEPCID ACJohnson & JohnsonN-020801 OTC2007-12-17
1 products, RLD, RS
FAMOTIDINESagent PharmaceuticalsN-219935 RX2025-07-16
3 products, RLD, RS
Show 9 discontinued
Calcium carbonate
+
Famotidine
+
Magnesium hydroxide
Tradename
Company
Number
Date
Products
PEPCID COMPLETEJohnson & JohnsonN-020958 OTC2000-10-16
1 products, RLD, RS
Famotidine
+
Ibuprofen
Tradename
Company
Number
Date
Products
DUEXISHorizon Therapeutics PublicN-022519 DISCN2011-04-23
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
acid controllerANDA2025-09-15
acid reducerANDA2025-09-18
acid reducer completeANDA2025-08-27
acid reducer plus antacidANDA2025-08-11
acid reliefANDA2025-09-18
amazon basic care acid reducerANDA2025-09-04
basic care acid reducerANDA2025-02-10
basic care dual action completeANDA2022-07-11
basic care famotidineANDA2020-02-19
basic care heartburn preventionANDA2025-09-18
Show 66 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gastroesophageal refluxEFO_0003948D005764K21
helicobacter infectionsEFO_1000961D016481—
peptic esophagitisEFO_1001095D004942—
stomach ulcer—D013276K25
duodenal ulcerEFO_0004607D004381K26
dyspepsiaEFO_0008533D004415K30
zollinger-ellison syndrome—D015043E16.4
urticariaEFO_0005531D014581L50
heartburn—D006356R12
juvenile arthritisEFO_1002007D001171M08
Show 15 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Famotidine / Ibuprofen, Duexis, Horizon
80674512026-07-18DPU-1196
83091272026-07-18DP
83182022026-07-18DP
84499102026-07-18DP
85012282026-07-18U-1196
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BA: H2-receptor antagonists
— A02BA03: Famotidine
— A02BA53: Famotidine, combinations
HCPCS
Code
Description
S0028
Injection, famotidine, 20 mg
Clinical
Clinical Trials
8101 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AdenocarcinomaD000230———2———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C805————5
Stomach neoplasmsD013274EFO_0003897C164————4
Ovarian neoplasmsD010051EFO_0003893C563————3
Non-small-cell lung carcinomaD002289——3————3
Breast neoplasmsD001943EFO_0003869C502————2
Lung neoplasmsD008175—C34.902————2
Colonic neoplasmsD003110—C182————2
Triple negative breast neoplasmsD064726——2————2
Pancreatic neoplasmsD010190EFO_0003860C252————2
Hepatocellular carcinomaD006528—C22.01————1
Show 10 more
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFamotidine
INNfamotidine
Description
Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour.
Classification
Small molecule
Drug classH2-receptor antagonists (cimetidine type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NC(N)=Nc1nc(CSCC/C(N)=N/S(N)(=O)=O)cs1
Identifiers
PDB—
CAS-ID76824-35-6
RxCUI—
ChEMBL IDCHEMBL902
ChEBI ID4975
PubChem CID5702160
DrugBankDB00927
UNII ID5QZO15J2Z8 (ChemIDplus, GSRS)
Target
Agency Approved
HRH2
HRH2
Organism
Homo sapiens
Gene name
HRH2
Gene synonyms
NCBI Gene ID
3274
Protein name
histamine H2 receptor
Protein synonyms
gastric receptor 1, Gastric receptor I
Uniprot ID
P25021
Mouse ortholog
Hrh2 (15466)
histamine H2 receptor (Q9D282)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Duexis – Horizon Therapeutics Public
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Estimated US medical usage
Famotidine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Famotidine
+
Ibuprofen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,172 documents
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Safety
Black-box Warning
Black-box warning for: Ibuprofen and famotidine, Ibuprofen famotidine
Adverse Events
Top Adverse Reactions
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15,473 adverse events reported
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