FRESOLIMUMAB
Fresolimumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against transforming growth factor beta-1 proprotein.
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Commercial
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 2 |
| Focal segmental glomerulosclerosis | D005923 | EFO_0004236 | — | 1 | 1 | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Malignant mesothelioma | D000086002 | — | — | — | 1 | — | — | — | 1 |
| Mesothelioma | D008654 | — | C45 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | — | — | — | — | 2 |
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Osteogenesis imperfecta | D010013 | — | Q78.0 | 1 | — | — | — | — | 1 |
| Essential thrombocythemia | D013920 | — | D47.3 | 1 | — | — | — | — | 1 |
| Polycythemia vera | D011087 | — | D45 | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Thrombocytosis | D013922 | — | D75.83 | 1 | — | — | — | — | 1 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | 1 | — | — | — | — | 1 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | 1 | — | — | — | — | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FRESOLIMUMAB |
| INN | fresolimumab |
| Description | Fresolimumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743022 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 375142VBIA (ChemIDplus, GSRS) |
Target
Agency Approved
TGFB1
TGFB1
Organism
Homo sapiens
Gene name
TGFB1
Gene synonyms
TGFB
NCBI Gene ID
Protein name
transforming growth factor beta-1 proprotein
Protein synonyms
latency-associated peptide, prepro-transforming growth factor beta-1, TGF-beta-1, transforming growth factor beta1
Uniprot ID
Mouse ortholog
Tgfb1 (21803)
transforming growth factor beta-1 proprotein (P04202)
Alternate
No data
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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