FORODESINE
Forodesine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against purine nucleoside phosphorylase.
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Commercial
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 4 | 7 | — | — | — | 8 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | 6 | — | — | — | 7 |
| Lymphoma | D008223 | — | C85.9 | 4 | 5 | — | — | — | 6 |
| T-cell lymphoma | D016399 | — | — | 4 | 4 | — | — | — | 5 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 2 | — | — | — | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 2 | 3 | — | — | — | 3 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 2 | 3 | — | — | — | 3 |
| T-cell lymphoma cutaneous | D016410 | — | — | 2 | 2 | — | — | — | 3 |
| Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 2 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 2 | — | — | — | 2 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FORODESINE |
| INN | forodesine |
| Description | Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12 |
Identifiers
| PDB | — |
| CAS-ID | 209799-67-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL218291 |
| ChEBI ID | 43362 |
| PubChem CID | 444499 |
| DrugBank | — |
| UNII ID | 426X066ELK (ChemIDplus, GSRS) |
Target
Agency Approved
PNP
PNP
Organism
Homo sapiens
Gene name
PNP
Gene synonyms
NP
NCBI Gene ID
Protein name
purine nucleoside phosphorylase
Protein synonyms
epididymis secretory sperm binding protein Li 156an, HEL-S-156an, Inosine phosphorylase, Inosine-guanosine phosphorylase, purine-nucleoside:orthophosphate ribosyltransferase
Uniprot ID
Mouse ortholog
Pnp (18950)
purine nucleoside phosphorylase (P23492)
Alternate
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Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 372 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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32 adverse events reported
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