Ezogabine
Potiga (ezogabine) is a small molecule pharmaceutical. Ezogabine was first approved as Potiga on 2011-06-10. It is used to treat partial epilepsies in the USA. The pharmaceutical is active against potassium voltage-gated channel subfamily KQT member 5, potassium voltage-gated channel subfamily KQT member 3, potassium voltage-gated channel subfamily KQT member 2, and potassium voltage-gated channel subfamily KQT member 4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| partial epilepsies | EFO_0004263 | D004828 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
30 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lennox gastaut syndrome | D065768 | — | G40.81 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | — | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Partial epilepsies | D004828 | EFO_0004263 | — | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary retention | D016055 | — | R33 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ezogabine |
| INN | retigabine |
| Description | Ezogabine is a substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults. It has a role as an anticonvulsant and a potassium channel modulator. It is a carbamate ester, an organofluorine compound, a substituted aniline and a secondary amino compound. It is functionally related to a benzene-1,2,4-triamine. |
| Classification | Small molecule |
| Drug class | gabamimetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N |
Identifiers
| PDB | — |
| CAS-ID | 150812-12-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL41355 |
| ChEBI ID | 68584 |
| PubChem CID | 121892 |
| DrugBank | DB04953 |
| UNII ID | 12G01I6BBU (ChemIDplus, GSRS) |
Target
Agency Approved
KCNQ5
KCNQ5
KCNQ3
KCNQ3
KCNQ2
KCNQ2
KCNQ4
KCNQ4
Organism
Homo sapiens
Gene name
KCNQ5
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily KQT member 5
Protein synonyms
KQT-like 5, potassium channel protein, Potassium channel subunit alpha KvLQT5, potassium channel, voltage gated KQT-like subfamily Q, member 5, Voltage-gated potassium channel subunit Kv7.5
Uniprot ID
Mouse ortholog
Kcnq5 (226922)
potassium voltage-gated channel subfamily KQT member 5 (Q9JK45)
Alternate
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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760 adverse events reported
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