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AboutPricing
Drug ReportsExenatide
Byetta(exenatide)
Bydureon, Byetta (exenatide) is a protein pharmaceutical. Exenatide was first approved as Byetta on 2005-04-28. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against glucagon-like peptide 1 receptor.
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5D
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YTD
1Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Bydureon, Byetta
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Exenatide synthetic
Tradename
Company
Number
Date
Products
BYETTAAstraZenecaN-021773 RX2005-04-28
2 products, RLD, RS
BYDUREON BCISEAstraZenecaN-209210 RX2017-10-20
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bydureon bciseNew Drug Application2023-05-04
byettaNew Drug Application2022-12-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
Expiration
Code
EXENATIDE SYNTHETIC, BYDUREON, ASTRAZENECA AB
2025-01-22PED
2024-07-22NPP
EXENATIDE SYNTHETIC, BYDUREON BCISE, ASTRAZENECA AB
2025-01-22PED
2024-07-22NPP
EXENATIDE SYNTHETIC, BYDUREON PEN, ASTRAZENECA AB
2025-01-22PED
2024-07-22NPP
EXENATIDE SYNTHETIC, BYETTA, ASTRAZENECA AB
2024-11-04M-232
Patent Expiration
Patent
Expires
Flag
FDA Information
Exenatide Synthetic, Bydureon Bcise, Astrazeneca Ab
88950332030-10-04DPU-2589, U-2590, U-2597, U-2601, U-2602, U-3188, U-3189, U-3190
Exenatide Synthetic, Bydureon, Astrazeneca Ab
87216152030-01-18DP
89988762030-01-07DP
86908372029-05-19DP
88279632029-02-04DP
84398642028-03-25DP
93208532028-03-25DP
83619722028-03-21U-2588
82161802028-01-12DP
87582922027-11-12DP
85016982027-06-20DPU-2588
83296482026-08-18U-2588, U-2589, U-2590, U-2593, U-2594, U-2595, U-2596, U-3188, U-3189, U-3190
89068512026-08-18U-2588, U-2589, U-2590, U-2593, U-2597, U-3188, U-3189, U-3190
98840922026-08-18U-2588, U-2589, U-2590, U-2593, U-2594, U-2595, U-2596, U-2597, U-3188, U-3189, U-3190
65151172025-10-04DS, DPU-2588
74562542025-06-30DPU-2588, U-2589, U-2590, U-3188, U-3189, U-3190
76121762025-04-13DPU-2588, U-2589, U-2590, U-3188, U-3189, U-3190
84316852025-04-13DPU-2588, U-2589, U-2590, U-2597, U-3188, U-3189, U-3190
84611052025-04-13DPU-2588, U-2589, U-2590, U-2597, U-3188, U-3189, U-3190
75638712024-04-15DP
92380762024-04-15DPU-2588, U-2589, U-2590, U-2597, U-2599, U-3188, U-3189, U-3190
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BJ: Glucagon-like peptide-1 (glp-1) analogues
— A10BJ01: Exenatide
HCPCS
No data
Clinical
Clinical Trials
375 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E112223685048205
ObesityD009765EFO_0001073E66.949910737
Diabetes mellitusD003920HP_0000819E08-E134722619
Type 1 diabetes mellitusD003922EFO_0001359E104833216
Healthy volunteers/patients———7——3313
Polycystic ovary syndromeD011085EFO_0000660E28.2—224—7
Glucose intoleranceD018149HP_0000833R73.03———7—7
Myocardial infarctionD009203EFO_0000612I21—1—4—5
Cardiovascular diseasesD002318HP_0001626————134
OverweightD050177—E66.311—2—4
Show 26 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20151——7
HypoglycemiaD007003HP_0001943E16.2331—15
CraniopharyngiomaD003397———11——2
Morbid obesityD009767EFO_0001074——21——2
Weight lossD015431HP_0001824———1—12
Pediatric obesityD063766————1——1
St elevation myocardial infarctionD000072657————1——1
Chronic renal insufficiencyD051436—N18——1——1
Left ventricular dysfunctionD018487————1——1
Metabolic syndromeD024821EFO_0000195E88.810——1——1
Show 1 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InsulinomaD007340——51——16
Congenital hyperinsulinismD044903——21——13
AlcoholismD000437EFO_0003829F10.121———3
Smoking cessationD016540EFO_0004319—22———3
Ischemic strokeD000083242———2———2
StrokeD020521EFO_0000712I63.9—1——12
Cocaine-related disordersD019970—F1421———2
Autoimmune diseasesD001327HP_0002960M30-M3611———1
Multiple system atrophyD019578———1———1
Septic shockD012772—A48.311———1
Show 5 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437HP_0000083N191———12
NesidioblastosisD046768EFO_0007318E16.91————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperinsulinismD006946HP_0000842E16.1————33
Prader-willi syndromeD011218Orphanet_739Q87.11————22
Papillary thyroid cancerD000077273——————11
Coronary diseaseD003327——————11
Aortic valve diseaseD000082862——————11
Cardiogenic shockD012770—R57.0————11
Heart arrestD006323EFO_0009492I46————11
ComaD003128HP_0001259R40.2————11
PsoriasisD011565EFO_0000676L40————11
Postpartum depressionD019052EFO_0007453F53.0————11
Show 10 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameExenatide
INNexenatide
Description
EXENATIDE
Classification
Protein
Drug classpeptides
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Identifiers
PDB—
CAS-ID141758-74-9
RxCUI—
ChEMBL IDCHEMBL414357
ChEBI ID—
PubChem CID16157882
DrugBankDB01276
UNII ID9P1872D4OL (ChemIDplus, GSRS)
Target
Agency Approved
GLP1R
GLP1R
Organism
Homo sapiens
Gene name
GLP1R
Gene synonyms
NCBI Gene ID
2740
Protein name
glucagon-like peptide 1 receptor
Protein synonyms
GLP-1 receptor, GLP1 receptor, seven transmembrane helix receptor
Uniprot ID
Q99669
Mouse ortholog
Glp1r (14652)
glucagon-like peptide 1 receptor (Q1JQR8)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Byetta – Amylin Pharmaceuticals
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Byetta – AstraZeneca
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Byetta – Bristol Myers Squibb
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Exenatide – Eli Lilly
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Bydureon – Alkermes
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Bydureon – AstraZeneca
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Bydureon – Bristol Myers Squibb
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Tabular view
Estimated US medical usage
Exenatide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15,619 documents
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Safety
Black-box Warning
Black-box warning for: Bydureon bcise
Adverse Events
Top Adverse Reactions
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78,867 adverse events reported
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