Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 3 | 1 | — | 1 | 8 |
Sarcoma | D012509 | — | — | 1 | 2 | 1 | — | 1 | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Prostatic neoplasms | D011471 | — | C61 | 2 | 1 | — | — | — | 2 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 2 |
Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 1 | — | — | — | 2 |
Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 1 |
Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
Biliary tract neoplasms | D001661 | — | C24.9 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 5 | — | — | — | — | 5 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | — | — | — | — | 2 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
Drug common name | Evofosfamide |
INN | evofosfamide |
Description | Evofosfamide (INN, USAN; formerly known as TH-302). Is a compound being evaluated in clinical trials for the treatment of multiple tumor types as a monotherapy and in combination with chemotherapeutic agents and other targeted cancer drugs.
|
Classification | Small molecule |
Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+](=O)[O-] |
PDB | — |
CAS-ID | 918633-87-1 |
RxCUI | — |
ChEMBL ID | CHEMBL260046 |
ChEBI ID | — |
PubChem CID | 11984561 |
DrugBank | — |
UNII ID | 8A9RZ3HN8W (ChemIDplus, GSRS) |