Evofosfamide
Evofosfamide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 5 | 4 | 1 | — | 1 | 9 |
| Sarcoma | D012509 | — | — | 1 | 2 | 1 | — | 1 | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 3 | 2 | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | 1 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 1 | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | — | — | — | — | 6 |
| Hypoxia | D000860 | — | R09.02 | 3 | — | — | — | 1 | 4 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | — | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | — | — | — | — | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | — | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | 1 | — | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Evofosfamide |
| INN | evofosfamide |
| Description | Evofosfamide (INN, USAN; formerly known as TH-302). Is a compound being evaluated in clinical trials for the treatment of multiple tumor types as a monotherapy and in combination with chemotherapeutic agents and other targeted cancer drugs.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+](=O)[O-] |
Identifiers
| PDB | — |
| CAS-ID | 918633-87-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL260046 |
| ChEBI ID | — |
| PubChem CID | 11984561 |
| DrugBank | DB06091 |
| UNII ID | 8A9RZ3HN8W (ChemIDplus, GSRS) |
Target
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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35 adverse events reported
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