Evocalcet
Evocalcet is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against extracellular calcium-sensing receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
No data
Clinical
Clinical Trials
9 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | 2 | 3 | 5 | — | — | 8 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | 2 | 3 | 4 | — | — | 7 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 2 | 4 | — | — | 6 |
| Carcinoma | D002277 | — | C80.0 | — | — | 1 | — | — | 1 |
| Parathyroid neoplasms | D010282 | — | — | — | — | 1 | — | — | 1 |
| Primary hyperparathyroidism | D049950 | EFO_0008519 | E21.0 | — | — | 1 | — | — | 1 |
| Hypercalcemia | D006934 | HP_0003072 | E83.52 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Evocalcet |
| INN | evocalcet |
| Description | Evocalcet (trade name Orkedia) is a drug for the treatment of hyperparathyroidism. It acts as a calcium-sensing receptor agonist.
|
| Classification | Small molecule |
| Drug class | calcium-sensing receptor (CaSR) agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](N[C@H]1CCN(c2ccc(CC(=O)O)cc2)C1)c1cccc2ccccc12 |
Identifiers
| PDB | — |
| CAS-ID | 870964-67-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297621 |
| ChEBI ID | — |
| PubChem CID | 71242808 |
| DrugBank | DB12388 |
| UNII ID | E58MLH082P (ChemIDplus, GSRS) |
Target
Agency Approved
CASR
CASR
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 171 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
47 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use