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Drug ReportsEtoposide
Etoposide
Etopophos, Etoposide (etoposide) is a small molecule pharmaceutical. Etoposide was first approved as Vepesid on 1983-11-10. It is used to treat brain neoplasms, ewing sarcoma, histiocytosis, kaposi sarcoma, and lung neoplasms amongst others in the USA. The pharmaceutical is active against DNA topoisomerase 2-alpha.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
respiratory tract diseasesD012140
nervous system diseasesD009422
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
endocrine system diseasesD004700
immune system diseasesD007154
Trade Name
FDA
EMA
Etopophos, Etoposide (discontinued: Etopophos, Etoposide, Toposar, Vepesid)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etoposide
Tradename
Company
Number
Date
Products
VEPESIDCordenPharmaN-018768 DISCN1983-11-10
1 products, RLD
VEPESIDStrides Pharma GlobalN-019557 DISCN1986-12-30
2 products, RLD
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Etoposide phosphate
Tradename
Company
Number
Date
Products
ETOPOPHOS PRESERVATIVE FREECHEPLAPHARM ArzneimittelN-020457 RX1996-05-17
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
etopophosNew Drug Application2024-12-31
etoposideANDA2025-05-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
myeloid leukemia acute—D015470C92.0
prostatic neoplasms—D011471C61
brain neoplasmsEFO_0003833D001932C71
lung neoplasms—D008175C34.90
neuroblastomaEFO_0000621D009447—
urinary bladder neoplasms—D001749C67
uterine neoplasmsEFO_0003859D014594C55
mycosis fungoides—D009182C84.0
testicular neoplasms—D013736C62
ewing sarcomaEFO_0000173D012512—
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CB: Podophyllotoxin derivatives, antineoplastic drugs
— L01CB01: Etoposide
HCPCS
Code
Description
J8560
Etoposide; oral, 50 mg
J9181
Injection, etoposide, 10 mg
Clinical
Clinical Trials
1940 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hodgkin diseaseD006689—C8111———2
NeoplasmsD009369—C80—1———1
Multiple myelomaD009101—C90.0—1———1
Plasma cell neoplasmsD054219———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C951————1
Hematologic neoplasmsD019337——1————1
Non-hodgkin lymphomaD008228—C85.91————1
LymphomaD008223—C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEtoposide
INNetoposide
Description
Etoposide is a beta-D-glucoside, a furonaphthodioxole and an organic heterotetracyclic compound. It has a role as an antineoplastic agent and a DNA synthesis inhibitor. It is functionally related to a podophyllotoxin and a 4'-demethylepipodophyllotoxin.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cc([C@@H]2c3cc4c(cc3[C@@H](O[C@@H]3O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O
Identifiers
PDB—
CAS-ID33419-42-0
RxCUI—
ChEMBL IDCHEMBL44657
ChEBI ID4911
PubChem CID36462
DrugBankDB00773
UNII ID6PLQ3CP4P3 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TOP2B
TOP2B
Organism
Homo sapiens
Gene name
TOP2B
Gene synonyms
NCBI Gene ID
7155
Protein name
DNA topoisomerase 2-beta
Protein synonyms
antigen MLAA-44, DNA topoisomerase II, 180 kD, DNA topoisomerase II, beta isozyme, topo II beta, topoisomerase (DNA) II beta 180kDa, topoisomerase II beta, topoisomerase IIb, U937 associated antigen
Uniprot ID
Q02880
Mouse ortholog
Top2b (21974)
DNA topoisomerase 2-beta (Q7TQG4)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Etoposide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 77,169 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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66,250 adverse events reported
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