Etoposide
Etopophos, Etoposide (etoposide) is a small molecule pharmaceutical. Etoposide was first approved as Vepesid on 1983-11-10. It is used to treat brain neoplasms, ewing sarcoma, histiocytosis, kaposi sarcoma, and lung neoplasms amongst others in the USA. The pharmaceutical is active against DNA topoisomerase 2-alpha.
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Etopophos, Etoposide (discontinued: Etopophos, Etoposide, Toposar, Vepesid)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etoposide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VEPESID | CordenPharma | N-018768 DISCN | 1983-11-10 | 1 products, RLD |
| VEPESID | Strides Pharma Global | N-019557 DISCN | 1986-12-30 | 2 products, RLD |
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Etoposide phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ETOPOPHOS PRESERVATIVE FREE | CHEPLAPHARM Arzneimittel | N-020457 RX | 1996-05-17 | 1 products, RLD, RS |
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Clinical Trials
1940 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 107 | 355 | 95 | 15 | 40 | 547 |
| Small cell lung carcinoma | D055752 | — | — | 58 | 179 | 69 | 4 | 27 | 304 |
| Lung neoplasms | D008175 | — | C34.90 | 67 | 165 | 63 | 4 | 23 | 286 |
| Leukemia | D007938 | — | C95 | 73 | 137 | 77 | 6 | 21 | 273 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 59 | 143 | 34 | 5 | 9 | 213 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 35 | 77 | 40 | 9 | 18 | 158 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 47 | 92 | 21 | 1 | 8 | 146 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 48 | 55 | 40 | 1 | 11 | 136 |
| B-cell lymphoma | D016393 | — | — | 47 | 82 | 18 | 3 | 6 | 131 |
| Hodgkin disease | D006689 | — | C81 | 27 | 80 | 27 | 2 | 7 | 122 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia | D007951 | — | C92 | 33 | 45 | 29 | — | 12 | 105 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 20 | 35 | 21 | — | 5 | 77 |
| Multiple myeloma | D009101 | — | C90.0 | 12 | 45 | 10 | — | 6 | 69 |
| Sarcoma | D012509 | — | — | 14 | 32 | 16 | — | 6 | 64 |
| Recurrence | D012008 | — | — | 21 | 33 | 6 | — | 5 | 57 |
| Myelodysplastic syndromes | D009190 | — | D46 | 22 | 26 | 13 | — | 3 | 55 |
| Plasma cell neoplasms | D054219 | — | — | 9 | 34 | 8 | — | 4 | 53 |
| Central nervous system neoplasms | D016543 | — | — | 9 | 28 | 7 | — | 5 | 48 |
| Carcinoma | D002277 | — | C80.0 | 6 | 31 | 9 | — | 4 | 47 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 13 | 27 | 8 | — | 2 | 44 |
Show 118 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 8 | 17 | — | — | 6 | 28 |
| Plasmacytoma | D010954 | — | C90.3 | 5 | 14 | — | — | 2 | 21 |
| Hematologic neoplasms | D019337 | — | — | 8 | 7 | — | — | 3 | 17 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 6 | 10 | — | — | 4 | 17 |
| Graft vs host disease | D006086 | — | D89.81 | 3 | 7 | — | — | 3 | 12 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | 6 | — | — | 2 | 10 |
| Aids-related lymphoma | D016483 | EFO_1001365 | — | 3 | 6 | — | — | 1 | 10 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 2 | 7 | — | — | 1 | 10 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 5 | 2 | — | — | 3 | 9 |
| Mycosis fungoides | D009182 | — | C84.0 | 5 | 3 | — | — | 2 | 9 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large granular lymphocytic leukemia | D054066 | — | — | 2 | — | — | — | 2 | 4 |
| Neuroepithelial neoplasms | D018302 | — | — | 2 | — | — | — | — | 2 |
| Pharyngeal neoplasms | D010610 | — | C14.0 | 2 | — | — | — | — | 2 |
| Peritoneal neoplasms | D010534 | — | — | 2 | — | — | — | — | 2 |
| Mesothelioma | D008654 | — | C45 | 2 | — | — | — | — | 2 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 2 | — | — | — | — | 2 |
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Thymus neoplasms | D013953 | — | C37 | 1 | — | — | — | 1 | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Urethral neoplasms | D014523 | EFO_0003846 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 2 | 2 |
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | — | — | — | 1 | 1 |
| Hemoglobinuria | D006456 | — | R82.3 | — | — | — | — | 1 | 1 |
| Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 1 | 1 |
| Ataxia | D001259 | — | R27.0 | — | — | — | — | 1 | 1 |
| Ataxia telangiectasia | D001260 | Orphanet_100 | G11.3 | — | — | — | — | 1 | 1 |
| Telangiectasis | D013684 | — | — | — | — | — | — | 1 | 1 |
| Cerebellar ataxia | D002524 | — | — | — | — | — | — | 1 | 1 |
| Peripheral blood stem cell transplantation | D036102 | — | — | — | — | — | — | 1 | 1 |
| Wiskott-aldrich syndrome | D014923 | EFO_0003903 | D82.0 | — | — | — | — | 1 | 1 |
Show 15 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Etoposide |
| INN | etoposide |
| Description | Etoposide is a beta-D-glucoside, a furonaphthodioxole and an organic heterotetracyclic compound. It has a role as an antineoplastic agent and a DNA synthesis inhibitor. It is functionally related to a podophyllotoxin and a 4'-demethylepipodophyllotoxin. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc([C@@H]2c3cc4c(cc3[C@@H](O[C@@H]3O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]3O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O |
Identifiers
| PDB | — |
| CAS-ID | 33419-42-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL44657 |
| ChEBI ID | 4911 |
| PubChem CID | 36462 |
| DrugBank | DB00773 |
| UNII ID | 6PLQ3CP4P3 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
TOP2B
TOP2B
Organism
Homo sapiens
Gene name
TOP2B
Gene synonyms
NCBI Gene ID
Protein name
DNA topoisomerase 2-beta
Protein synonyms
antigen MLAA-44, DNA topoisomerase II, 180 kD, DNA topoisomerase II, beta isozyme, topo II beta, topoisomerase (DNA) II beta 180kDa, topoisomerase II beta, topoisomerase IIb, U937 associated antigen
Uniprot ID
Mouse ortholog
Top2b (21974)
DNA topoisomerase 2-beta (Q7TQG4)
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Etoposide
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Safety
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66,250 adverse events reported
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