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Drug ReportsEtonogestrel
Etonogestrel
Eluryng, Enilloring, Ethinyl Estradiol / Etonogestrel, Haloette, Nexplanon, Nuvaring (etonogestrel) is a small molecule pharmaceutical. Etonogestrel was first approved as Nuvaring on 2001-10-03.
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Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
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2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Nexplanon (discontinued: Nexplanon)
Combinations
Eluryng, Enilloring, Ethinyl estradiol; etonogestrel, Haloette, Nuvaring (discontinued: Veraring)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etonogestrel
Tradename
Company
Number
Date
Products
NEXPLANONOrganonN-021529 RX2011-05-13
1 products, RLD, RS
Show 1 discontinued
Ethinyl estradiol
+
Etonogestrel
Tradename
Company
Number
Date
Products
NUVARINGOrganonN-021187 RX2001-10-03
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
nexplanonNew Drug Application2024-12-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
prostatic neoplasms—D011471C61
breast neoplasmsEFO_0003869D001943C50
menorrhagiaEFO_0003945D008595N92.0
primary ovarian insufficiencyEFO_0004266D016649E28.3
hot flashes—D019584—
hypogonadism—D007006E23.0
premature menopause—D008594E28.31
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Etonogestrel, Implanon, Organon
97575522030-07-28DPU-1
87220372027-09-28DP
108212772027-05-31DP
88887452026-08-28DP
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AC: Progestogen systemic hormonal contraceptives
— G03AC08: Etonogestrel
HCPCS
Code
Description
J7295
Ethinyl estradiol and etonogestrel 0.015mg, 0.12mg per 24 hours; monthly vaginal ring, each
J7307
Etonogestrel (contraceptive) implant system, including implant and supplies
Clinical
Clinical Trials
150 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ContraceptionD003267———364114
HemorrhageD006470MP_0001914R58———123
Uterine hemorrhageD014592———2—1—3
MetrorrhagiaD008796—N92.1———112
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DysmenorrheaD004412—N94.6—12——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperplasiaD006965EFO_0000536——1——12
Prostatic hyperplasiaD011470EFO_0000284N40—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.11———23
Pregnancy rateD018873——1————1
Migraine disordersD008881EFO_0003821G431————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hormonal contraceptionD000080282——————22
Body weightD001835EFO_0004338—————22
Weight lossD015431——————22
ObesityD009765EFO_0001073E66.9————22
MicrobiotaD064307——————11
PharmacokineticsD010599——————11
Opioid-related disordersD009293EFO_0005611F11————11
Sexual behaviorD012725——————11
Sexually transmitted diseasesD012749—A50-A64————11
Body weight changesD001836——————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEtonogestrel
INNetonogestrel
Description
Etonogestrel is a medication which is used as a means of birth control for women. It is available as an implant placed under the skin of the upper arm under the brand names Nexplanon and Implanon. It is a progestin that is also used in combination with ethinylestradiol, an estrogen, as a vaginal ring under the brand names NuvaRing and Circlet. Etonogestrel is effective as a means of birth control and lasts at least three or four years with some data showing effectiveness for five years. Following removal, fertility quickly returns.
Classification
Small molecule
Drug classestrogens; progestins
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3C(=C)C[C@@]21CC
Identifiers
PDB—
CAS-ID54048-10-1
RxCUI—
ChEMBL IDCHEMBL1531
ChEBI ID50777
PubChem CID21729469
DrugBankDB00294
UNII ID304GTH6RNH (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Nexplanon – Organon
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Nexplanon – Merck & Co
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Nuvaring – Organon
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Nuvaring – Merck & Co
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Tabular view
Estimated US medical usage
Etonogestrel
+
Ethinyl estradiol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Etonogestrel
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,865 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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67,321 adverse events reported
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