Etomidate
Amidate, Etomidate (etomidate) is a small molecule pharmaceutical. Etomidate was first approved as Amidate on 1982-09-07. It is used to treat brain ischemia, closed head injuries, pain, and status epilepticus in the USA.
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Commercial
Trade Name
FDA
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Amidate, Etomidate (discontinued: Etomidate)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| amidate | New Drug Application | 2024-03-22 |
| amidate(tm) etomidate | New Drug Application | 2023-10-10 |
| etomidate | ANDA | 2024-03-15 |
| etomidate injection, solution | ANDA | 2023-09-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| brain ischemia | EFO_0003883 | D002545 | I67.82 |
| closed head injuries | — | D016489 | — |
| status epilepticus | EFO_0008526 | D013226 | G41 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
122 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | 2 | 7 | 5 | 14 |
| General anesthesia | D000768 | — | — | 1 | — | — | 4 | 1 | 6 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | 2 | 3 | 5 |
| Delirium | D003693 | — | R41.0 | — | — | — | 2 | 2 | 4 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 4 | — | 4 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | 2 | 2 | 4 |
| Myoclonus | D009207 | HP_0012323 | G25.3 | — | — | — | 3 | 1 | 4 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | 3 | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | 2 | — | 3 |
| Hemodynamics | D006439 | — | — | — | — | — | 3 | — | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | 1 | 1 | — | 2 | 3 |
| Conduction anesthesia | D000765 | — | — | — | — | 1 | — | 1 | 2 |
| Adrenal gland neoplasms | D000310 | EFO_0003850 | C74 | — | — | 1 | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | — | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | — | 1 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | — | 1 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | 1 | 1 | — | — | — | 1 |
| Gastroscopy | D005773 | — | — | — | 1 | — | — | — | 1 |
| Colonoscopy | D003113 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug overdose | D062787 | — | — | 1 | — | — | — | — | 1 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | HP_0001399 | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 5 | 5 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 2 | 2 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 2 | 2 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 2 | 2 |
| Unconsciousness | D014474 | HP_0007185 | R40.20 | — | — | — | — | 1 | 1 |
| Drug dose-response relationship | D004305 | — | — | — | — | — | — | 1 | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Intraoperative awareness | D058926 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Etomidate |
| INN | etomidate |
| Description | 3-(1-phenylethyl)-4-imidazolecarboxylic acid ethyl ester is a member of imidazoles. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)c1cncn1[C@H](C)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 33125-97-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL681 |
| ChEBI ID | 4910 |
| PubChem CID | 36339 |
| DrugBank | DB00292 |
| UNII ID | Z22628B598 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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942 adverse events reported
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