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Drug ReportsEthoxzolamide
Ethoxzolamide
Cardrase, Ethamide (ethoxzolamide) is a small molecule pharmaceutical. Ethoxzolamide was first approved as Cardrase on 1982-01-01. The pharmaceutical is active against carbonic anhydrase 14. In addition, it is known to target carbonic anhydrase 7, carbonic anhydrase 1, and carbonic anhydrase 12.
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Ethoxzolamide
Tradename
Company
Number
Date
Products
ETHAMIDEAllerganN-016144 DISCN1982-01-01
1 products
CARDRASEPharmacia & UpjohnN-011047 DISCN1982-01-01
2 products
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Drug
General
Drug common nameEthoxzolamide
INN_
Description
Ethoxzolamide is a sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a diuretic and an antiglaucoma drug. It is a member of benzothiazoles and a sulfonamide.
Classification
Small molecule
Drug classcarbonic anhydrase inhibitors
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Structure (InChI/SMILES or Protein Sequence)
CCOc1ccc2nc(S(N)(=O)=O)sc2c1
Identifiers
PDB—
CAS-ID452-35-7
RxCUI—
ChEMBL IDCHEMBL18
ChEBI ID101096
PubChem CID3295
DrugBankDB00311
UNII IDZ52H4811WX (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA4
CA4
Organism
Homo sapiens
Gene name
CA4
Gene synonyms
NCBI Gene ID
762
Protein name
carbonic anhydrase 4
Protein synonyms
CA-IV, Carbonate dehydratase IV, Carbonic anhydrase IV, carbonic dehydratase IV
Uniprot ID
Q6FHI7
Mouse ortholog
Car4 (12351)
carbonic anhydrase 4 (Q64444)
Variants
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Trends
PubMed Central
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85 adverse events reported
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