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Drug ReportsEthoxzolamide
Ethoxzolamide
Cardrase, Ethamide (ethoxzolamide) is a small molecule pharmaceutical. Ethoxzolamide was first approved as Ethamide on 1982-01-01. The pharmaceutical is active against carbonic anhydrase 14. In addition, it is known to target carbonic anhydrase 7, carbonic anhydrase 1, and carbonic anhydrase 12.
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Abbreviated New Drug Application (ANDA)
Ethoxzolamide
Tradename
Company
Number
Date
Products
ETHAMIDEAllerganN-016144 DISCN1982-01-01
1 products
CARDRASEPharmacia & UpjohnN-011047 DISCN1982-01-01
2 products
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Drug
General
Drug common nameEthoxzolamide
INN—
Description
Ethoxzolamide is a sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, a diuretic and an antiglaucoma drug. It is a member of benzothiazoles and a sulfonamide.
Classification
Small molecule
Drug classcarbonic anhydrase inhibitors
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Structure (InChI/SMILES or Protein Sequence)
CCOc1ccc2nc(S(N)(=O)=O)sc2c1
Identifiers
PDB—
CAS-ID452-35-7
RxCUI—
ChEMBL IDCHEMBL18
ChEBI ID101096
PubChem CID3295
DrugBankDB00311
UNII ID—
Target
Agency Approved
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Alternate
CA4
CA4
Organism
Homo sapiens
Gene name
CA4
Gene synonyms
NCBI Gene ID
762
Protein name
carbonic anhydrase 4
Protein synonyms
CA-IV, Carbonate dehydratase IV, Carbonic anhydrase IV, carbonic dehydratase IV
Uniprot ID
Q6FHI7
Mouse ortholog
Car4 (12351)
carbonic anhydrase 4 (Q64444)
Variants
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Trends
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63 adverse events reported
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