Ethosuximide
Zarontin (ethosuximide) is a small molecule pharmaceutical. Ethosuximide was first approved as Zarontin on 1982-01-01. It is used to treat absence epilepsy and epilepsy in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Zarontin (generic drugs available since 1982-01-01)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ethosuximide | ANDA | 2023-12-27 |
| zarontin | ANDA | 2023-07-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| absence epilepsy | HP_0011147 | D004832 | G40.A |
| epilepsy | EFO_0000474 | D004827 | G40.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | 1 | 2 | 2 | 5 |
| Intellectual disability | D008607 | EFO_0003847 | F73 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | 1 | — | — | 2 |
| Absence epilepsy | D004832 | HP_0011147 | G40.A | — | — | 2 | — | — | 2 |
| Ketogenic diet | D055423 | — | — | — | — | 1 | — | — | 1 |
| Seizures | D012640 | HP_0002069 | G40.4 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | — | — | 2 | — | — | — | 2 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | 1 | — | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ethosuximide |
| INN | ethosuximide |
| Description | Ethosuximide is a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures. It has a role as an anticonvulsant, a geroprotector and a T-type calcium channel blocker. It is a pyrrolidinone and a dicarboximide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC1(C)CC(=O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 77-67-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL696 |
| ChEBI ID | 4887 |
| PubChem CID | 3291 |
| DrugBank | DB00593 |
| UNII ID | 5SEH9X1D1D (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Ethosuximide
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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989 adverse events reported
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