Ethionamide
Trecator (ethionamide) is a small molecule pharmaceutical. Ethionamide was first approved as Trecator on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Trecator
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| trecator | New Drug Application | 2024-05-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| tuberculosis | EFO_0000774 | D014376 | A15-A19 |
| mycobacterium infections | — | D009164 | A31.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 3 | 2 | 1 | 5 | 10 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | 2 | 2 | 1 | 1 | 5 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Extensively drug-resistant tuberculosis | D054908 | — | — | — | 1 | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 1 | — | — | 2 | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | — | — | — | 1 |
| Frontotemporal dementia | D057180 | HP_0002145 | G31.0 | 1 | — | — | — | — | 1 |
| Primary progressive aphasia | D018888 | EFO_0009053 | G31.01 | 1 | — | — | — | — | 1 |
| Pick disease of the brain | D020774 | EFO_0003096 | G31.01 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 2 | 2 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ethionamide |
| INN | ethionamide |
| Description | Ethionamide is a thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. It has a role as an antitubercular agent, an antilipemic drug, a fatty acid synthesis inhibitor, a leprostatic drug and a prodrug. It is a member of pyridines and a thiocarboxamide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1cc(C(N)=S)ccn1 |
Identifiers
| PDB | — |
| CAS-ID | 536-33-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1441 |
| ChEBI ID | 4885 |
| PubChem CID | 2761171 |
| DrugBank | DB00609 |
| UNII ID | OAY8ORS3CQ (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Ethionamide
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Trends
PubMed Central
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Additional graphs summarizing 4,275 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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711 adverse events reported
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