Velcalcetide
Parsabiv (velcalcetide) is a protein pharmaceutical. Velcalcetide was first approved as Parsabiv on 2016-11-11. It has been approved in Europe to treat secondary hyperparathyroidism. It is known to target extracellular calcium-sensing receptor.
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Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | 5 | 5 | 9 | 1 | — | 20 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | 5 | 5 | 9 | 1 | — | 20 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 3 | 7 | 1 | 1 | 13 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 3 | 7 | 1 | 1 | 13 |
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | 1 | — | 1 |
| Cardiomegaly | D006332 | EFO_0002503 | I51.7 | — | — | — | 1 | — | 1 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 4 | 9 | — | — | 15 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone diseases | D001847 | — | M89.9 | — | 2 | — | — | 1 | 3 |
| Chronic kidney disease-mineral and bone disorder | D012080 | EFO_1001152 | N25.0 | — | 3 | — | — | — | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | 1 | — | — | — | 2 |
| Vascular calcification | D061205 | — | — | — | 1 | — | — | — | 1 |
| Calcinosis | D002114 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Velcalcetide |
| INN | etelcalcetide |
| Description | Etelcalcetide is an oligopeptide. |
| Classification | Protein |
| Drug class | peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N[C@H](CSSC[C@H](N)C(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](CCCNC(=N)N)C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1262780-97-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545184 |
| ChEBI ID | — |
| PubChem CID | 71511839 |
| DrugBank | DB12865 |
| UNII ID | 60ME133FJB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CASR
CASR
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Variants
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,694 adverse events reported
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