Esreboxetine
Esreboxetine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | 7 | — | 1 | — | 8 |
| Depression | D003863 | — | F33.9 | — | 1 | 1 | 2 | 3 | 7 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | 1 | 3 | 5 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | 1 | 3 | 5 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | 1 | 1 | — | 3 |
| Abdominal pain | D015746 | HP_0002027 | R10.9 | — | — | — | 1 | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | 1 | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 1 | — | 1 |
| Panic disorder | D016584 | EFO_0004262 | F41.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | 2 | 4 | — | — | 7 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | 4 | — | — | 5 |
| Narcolepsy | D009290 | HP_0030050 | G47.4 | — | 1 | 2 | — | — | 3 |
| Cataplexy | D002385 | HP_0002524 | — | — | 1 | 2 | — | — | 3 |
| Sleepiness | D000077260 | — | R40.0 | — | 1 | 2 | — | — | 3 |
| Disorders of excessive somnolence | D006970 | — | G47.1 | — | — | 2 | — | — | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary incontinence | D014549 | HP_0000020 | R32 | 1 | 2 | — | — | — | 3 |
| Stress urinary incontinence | D014550 | HP_0010992 | — | 1 | 2 | — | — | — | 3 |
| Enuresis | D004775 | — | R32 | 1 | 2 | — | — | — | 3 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | 2 | — | — | — | 2 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | — | — | — | 1 |
| Postherpetic neuralgia | D051474 | — | — | — | 1 | — | — | — | 1 |
| Hyperkinesis | D006948 | HP_0000752 | — | — | 1 | — | — | — | 1 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | — | — | — | 1 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 4 | 5 |
| Fecal incontinence | D005242 | — | R15 | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | — | — | — | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Decision making | D003657 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Esreboxetine |
| INN | esreboxetine |
| Description | (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine is an aromatic ether. |
| Classification | Small molecule |
| Drug class | antidepressants (fluoxetine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1ccccc1O[C@@H](c1ccccc1)[C@@H]1CNCCO1 |
Identifiers
| PDB | — |
| CAS-ID | 98819-76-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL180101 |
| ChEBI ID | — |
| PubChem CID | 65856 |
| DrugBank | — |
| UNII ID | L8S50ZY490 (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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353 adverse events reported
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