Esmolol
Brevibloc, Esmolol (esmolol) is a small molecule pharmaceutical. Esmolol was first approved as Brevibloc on 1988-08-15. It is used to treat angina pectoris, heart failure, hypertension, myocardial infarction, and supraventricular tachycardia amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Brevibloc, Esmolol (discontinued: Brevibloc, Esmolol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Esmolol hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BREVIBLOC IN PLASTIC CONTAINER | Baxter | N-019386 RX | 2001-02-16 | 1 products, RLD, RS |
| BREVIBLOC DOUBLE STRENGTH IN PLASTIC CONTAINER | Baxter | N-019386 RX | 2003-01-27 | 1 products, RLD, RS |
| BREVIBLOC | Baxter | N-019386 RX | 2003-02-25 | 1 products, RLD, RS |
| ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER | HQ Specialty Pharma | N-205703 RX | 2016-04-07 | 1 products, RLD, RS |
| ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER | HQ Specialty Pharma | N-205703 RX | 2016-04-07 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| brevibloc | New Drug Application | 2025-03-14 |
| esmolol | New Drug Application | 2017-01-18 |
| esmolol hydrochloride | ANDA | 2025-07-29 |
| esmolol hydrochloride in sodium chloride | ANDA | 2017-12-31 |
| esmolol hydrochloride in water | New Drug Application | 2024-05-31 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 4 | 4 | 8 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 2 | 3 | 6 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 1 | 2 | 3 | 6 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | — | 1 | 4 | 6 |
| Tachycardia | D013610 | — | R00.0 | — | 1 | 1 | 1 | 2 | 5 |
| Anesthesia | D000758 | — | — | — | — | 2 | 1 | 1 | 4 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | 1 | 2 | 4 |
| Vomiting | D014839 | — | R11.1 | — | — | — | 1 | 2 | 3 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | 1 | 1 | 3 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | 2 | 1 | 3 |
Show 31 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | — | 7 | 2 | — | 3 | 11 |
| Shock | D012769 | — | R57.1 | — | 6 | 2 | — | 3 | 10 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | 3 | 4 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | — | 3 | 4 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 1 | — | 3 | 4 |
| Ischemic stroke | D000083242 | — | — | — | — | 2 | — | 1 | 3 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | 1 | — | — | 2 |
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | — | — | 2 | — | — | 2 |
| Syndrome | D013577 | — | — | — | — | 1 | — | 1 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 1 | 1 | — | 1 | 2 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | — | 4 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | — | — | 2 | 3 |
| Toxemia | D014115 | — | — | — | 1 | — | — | 2 | 3 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 1 | — | — | 1 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 1 | — | — | — | 2 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | 2 | — | — | — | 2 |
| Intratracheal intubation | D007442 | — | — | 1 | 1 | — | — | 1 | 2 |
| Postoperative cognitive complications | D000079690 | — | — | 1 | 1 | — | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | — | 1 |
| Heart rate | D006339 | EFO_0004326 | — | — | 1 | — | — | — | 1 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Motor activity | D009043 | EFO_0003940 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 2 | 2 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | — | — | — | 1 | 1 |
| Confusion | D003221 | — | F44.89 | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 1 | 1 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 1 | 1 |
| Multiple chronic conditions | D000071069 | — | — | — | — | — | — | 1 | 1 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 1 | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | — | — | 1 | 1 |
| Bradycardia | D001919 | — | R00.1 | — | — | — | — | 1 | 1 |
Show 14 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Esmolol |
| INN | esmolol |
| Description | Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate is a methyl ester that is methyl 3-(4-hydroxyphenyl)propanoate in which the hydrogen attached to the phenolic hydroxy group is substituted by a 2-hydroxy-3-(isopropylamino)propyl group. It is an aromatic ether, a member of ethanolamines, a methyl ester, a secondary alcohol and a secondary amino compound. It is functionally related to a 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoic acid. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 103598-03-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL768 |
| ChEBI ID | 88206 |
| PubChem CID | 59768 |
| DrugBank | DB00187 |
| UNII ID | MDY902UXSR (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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626 adverse events reported
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