Esmirtazapine
Esmirtazapine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| mirtazapine | ANDA | 2025-10-03 |
| remeron | New Drug Application | 2012-02-17 |
| remeron remeronsoltab | New Drug Application | 2025-08-06 |
Indications
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Clinical
Clinical Trials
138 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Esmirtazapine |
| INN | esmirtazapine |
| Description | Esmirtazapine (ORG-50,081) is a tetracyclic antidepressant drug that was under development by Organon for the treatment of insomnia and vasomotor symptoms (e.g., hot flashes) associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology, including inverse agonist actions at H1 and 5-HT2 receptors and antagonist actions at α2-adrenergic receptors.
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| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN2c3ncccc3Cc3ccccc3[C@H]2C1 |
Identifiers
| PDB | — |
| CAS-ID | 61337-87-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1366933 |
| ChEBI ID | — |
| PubChem CID | 3085218 |
| DrugBank | DB06678 |
| UNII ID | 4685R51V7M (ChemIDplus, GSRS) |
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Remeron – Organon
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Additional graphs summarizing 11,966 documents
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Safety
Black-box Warning
Black-box warning for: Mirtazapine, Remeron, Remeron remeronsoltab
Adverse Events
0 adverse events reported
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