Esmethadone
Esmethadone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| diskets | New Drug Application | 2023-12-01 |
| diskets dispersible | 2007-08-03 | |
| methadone | 2007-10-06 | |
| methadone hcl | 2008-05-08 | |
| methadone hydrochloride | ANDA | 2025-09-09 |
| methadone hydrochloride methadose | 2006-09-19 | |
| methadone hydrochloride methadose dispersible | ANDA | 2024-06-28 |
| methadone hydrocloride | ANDA | 2025-05-29 |
| methadose | New Drug Application | 2024-07-24 |
| methadose methadose | New Drug Application | 2011-01-28 |
Show 1 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
37 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | 2 | 2 | 4 | 8 |
| Neuralgia | D009437 | EFO_0009430 | — | 2 | — | — | 1 | — | 3 |
| Heroin dependence | D006556 | EFO_0004240 | — | — | — | — | 1 | — | 1 |
| Free tissue flaps | D058752 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 1 | 6 | — | 1 | 8 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | 6 | — | 1 | 8 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | 6 | — | 1 | 8 |
| Pain | D010146 | EFO_0003843 | R52 | 2 | 1 | 1 | — | 1 | 4 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 2 | — | — | 2 |
| Hernia | D006547 | — | K40-K46 | — | — | 1 | — | — | 1 |
| Morphine dependence | D009021 | EFO_0005612 | — | — | — | 1 | — | — | 1 |
| Opiate substitution treatment | D058850 | — | — | — | — | 1 | — | — | 1 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | 1 | — | — | 1 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | 1 | 1 | — | — | 1 | 2 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | 1 | — | — | — | 1 |
| Psychomotor agitation | D011595 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 2 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 1 | 1 |
| Intractable pain | D010148 | — | — | — | — | — | — | 1 | 1 |
| Hiv seropositivity | D006679 | — | — | — | — | — | — | 1 | 1 |
| Cocaine-related disorders | D019970 | — | F14 | — | — | — | — | 1 | 1 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Esmethadone |
| INN | esmethadone |
| Description | Dextromethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. It has a role as a NMDA receptor antagonist and an opioid analgesic. It is an enantiomer of a levomethadone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(=O)C(C[C@H](C)N(C)C)(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 5653-80-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL350719 |
| ChEBI ID | — |
| PubChem CID | 643985 |
| DrugBank | DB15198 |
| UNII ID | S95RZH8AMH (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 41,387 documents
View more details
Safety
Black-box Warning
Black-box warning for: Diskets, Methadone, Methadone hydrochloride, Methadone hydrochloride methadose, Methadone hydrochloride methadose dispersible, Methadone hydrocloride, Methadose, Methadose methadose, Methadose methadose sugar-free
Adverse Events
0 adverse events reported
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use