Esflurbiprofen
Esflurbiprofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target prostaglandin G/H synthase 2.
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Variants
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| flurbiprofen sodium | ANDA | 2024-07-24 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | 1 | — | — | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ankle injuries | D016512 | — | S93.4 | — | 1 | — | — | — | 1 |
| Acute pain | D059787 | — | R52 | — | 1 | — | — | — | 1 |
| Sprains and strains | D013180 | — | — | — | 1 | — | — | — | 1 |
| Contusions | D003288 | — | T14.8 | — | 1 | — | — | — | 1 |
| Soft tissue injuries | D017695 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peritoneal dialysis | D010530 | — | — | — | — | — | — | 1 | 1 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Anesthesia | D000758 | — | — | — | — | — | — | 1 | 1 |
| Spinal anesthesia | D000775 | — | — | — | — | — | — | 1 | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
| Agnosia | D000377 | HP_0030222 | F88 | — | — | — | — | 1 | 1 |
| Patient-controlled analgesia | D016058 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Esflurbiprofen |
| INN | esflurbiprofen |
| Description | (S)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (R)-flurbiprofen. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 51543-39-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL435298 |
| ChEBI ID | 42446 |
| PubChem CID | 72099 |
| DrugBank | — |
| UNII ID | J5ZZK9P7MX (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PTGS2
PTGS2
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 31 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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