Escitalopram
Escitalopram Oxalate, Lexapro (escitalopram) is a small molecule pharmaceutical. Escitalopram was first approved as Lexapro on 2002-08-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| escitalopram | ANDA | 2025-04-09 |
| escitalopram oral solution | ANDA | 2025-03-05 |
| escitalopram oxalate | ANDA | 2025-04-08 |
| lexapro | New Drug Application | 2023-11-17 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ESCITALOPRAM OXALATE, LEXAPRO, ABBVIE | |||
| 2026-05-12 | NPP | ||
Patent Expiration
No data
HCPCS
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Clinical
Clinical Trials
700 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | 7 | — | — | 10 |
| Depression | D003863 | — | F33.9 | 1 | 2 | 5 | — | — | 8 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 7 | — | — | 7 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 2 | — | — | — | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Escitalopram |
| INN | escitalopram |
| Description | Escitalopram is a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram. It has a role as an antidepressant and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a conjugate base of an escitalopram(1+). It is an enantiomer of a (R)-citalopram. |
| Classification | Small molecule |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 |
Identifiers
| PDB | — |
| CAS-ID | 128196-01-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1508 |
| ChEBI ID | 36791 |
| PubChem CID | 146570 |
| DrugBank | DB01175 |
| UNII ID | 4O4S742ANY (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Escitalopram
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 17,143 documents
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Safety
Black-box Warning
Black-box warning for: Escitalopram, Escitalopram oral solution, Escitalopram oxalate, Lexapro
Adverse Events
Top Adverse Reactions
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37,858 adverse events reported
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