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AboutPricing
Drug ReportsEscitalopram
Escitalopram
Escitalopram Oxalate, Lexapro (escitalopram) is a small molecule pharmaceutical. Escitalopram was first approved as Lexapro on 2002-08-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name
Status
Last Update
escitalopramANDA2025-03-21
escitalopram oral solutionANDA2025-03-05
escitalopram oxalateANDA2025-01-20
lexaproNew Drug Application2023-11-17
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
ESCITALOPRAM OXALATE, LEXAPRO, ABBVIE
2026-05-12NPP
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AB: Selective serotonin reuptake inhibitors
— N06AB10: Escitalopram
HCPCS
No data
Clinical
Clinical Trials
699 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A127——10
DepressionD003863—F33.9125——8
Treatment-resistant depressive disorderD061218————7——7
RecurrenceD012008————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Major depressive disorderD003865EFO_0003761F2212———3
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEscitalopram
INNescitalopram
Description
Escitalopram is a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram. It has a role as an antidepressant and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a conjugate base of an escitalopram(1+). It is an enantiomer of a (R)-citalopram.
Classification
Small molecule
Drug classSelective serotonin reuptake inhibitor (SSRI)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21
Identifiers
PDB—
CAS-ID128196-01-0
RxCUI—
ChEMBL IDCHEMBL1508
ChEBI ID36791
PubChem CID146570
DrugBankDB01175
UNII ID4O4S742ANY (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Escitalopram
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 17,014 documents
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Safety
Black-box Warning
Black-box warning for: Escitalopram, Escitalopram oral solution, Escitalopram oxalate, Lexapro
Adverse Events
Top Adverse Reactions
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37,858 adverse events reported
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