Invanz(ertapenem)
Ertapenem, Invanz (ertapenem) is a small molecule pharmaceutical. Ertapenem was first approved as Invanz on 2001-11-21. It is used to treat abdominal abscess, bacterial infections, bacteroides infections, escherichia coli infections, and haemophilus infections amongst others in the USA. It has been approved in Europe to treat bacterial infections, bacterial pneumonia, community-acquired infections, gram-negative bacterial infections, and staphylococcal infections amongst others.
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Commercial
Trade Name
FDA
EMA
Ertapenem, Invanz (discontinued: Ertapenem)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ertapenem sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INVANZ | Merck & Co | N-021337 RX | 2001-11-21 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ertapenam | ANDA | 2021-05-27 |
| ertapenem | ANDA | 2024-11-06 |
| ertapenem sodium | ANDA | 2024-12-17 |
| invanz | New Drug Application | 2024-02-15 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J1335 | Injection, ertapenem sodium, 500 mg |
Clinical
Clinical Trials
89 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 2 | 9 | 1 | 1 | 13 |
| Communicable diseases | D003141 | — | — | — | 2 | 9 | 1 | 1 | 13 |
| Intraabdominal infections | D059413 | — | — | — | 1 | 2 | 1 | — | 4 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | — | — | 1 | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | — | — | 1 | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | 1 | — | 1 |
| Immediate hypersensitivity | D006969 | — | — | — | — | — | 1 | — | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | — | — | 1 | — | 1 |
| Continuous ambulatory peritoneal dialysis | D010531 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | 4 | — | 1 | 6 |
| Surgical wound infection | D013530 | — | — | — | 1 | 3 | — | — | 3 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 1 | — | — | 2 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | 2 | — | — | 2 |
| Abdominal injuries | D000007 | — | — | — | 1 | 1 | — | — | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 1 | — | — | 1 |
| Focal infection | D005490 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Soft tissue infections | D018461 | — | — | — | 1 | — | — | — | 1 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | — | — | — | 1 |
| Pelvic infection | D034161 | — | — | — | 1 | — | — | — | 1 |
| Pelvic inflammatory disease | D000292 | EFO_1001388 | N70-N77 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ertapenem |
| INN | ertapenem |
| Description | Ertapenem is meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract. It has a role as an antibacterial drug. It is a carbapenemcarboxylic acid and a pyrrolidinecarboxamide. It is a conjugate acid of an ertapenem(1-). |
| Classification | Small molecule |
| Drug class | antibacterial antibiotics, carbapenem derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 153832-46-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1359 |
| ChEBI ID | 404903 |
| PubChem CID | 150610 |
| DrugBank | DB00303 |
| UNII ID | G32F6EID2H (ChemIDplus, GSRS) |
Target
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Invanz – Merck & Co
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Safety
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5,317 adverse events reported
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