Invanz(ertapenem)
Ertapenem, Invanz (ertapenem) is a small molecule pharmaceutical. Ertapenem was first approved as Invanz on 2001-11-21. It is used to treat abdominal abscess, bacterial infections, bacteroides infections, escherichia coli infections, and haemophilus infections amongst others in the USA. It has been approved in Europe to treat bacterial infections, bacterial pneumonia, community-acquired infections, gram-negative bacterial infections, and staphylococcal infections amongst others.
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Commercial
Trade Name
FDA
EMA
Ertapenem, Invanz (discontinued: Ertapenem)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ertapenem sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INVANZ | Merck & Co | N-021337 RX | 2001-11-21 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ertapenam | ANDA | 2021-05-27 |
| ertapenem | ANDA | 2024-11-04 |
| ertapenem sodium | ANDA | 2023-12-28 |
| invanz | New Drug Application | 2024-02-15 |
Indications
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Agency Specific
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EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J1335 | Injection, ertapenem sodium, 500 mg |
Clinical
Clinical Trials
88 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 6 | 20 | 8 | 4 | 36 |
| Communicable diseases | D003141 | — | — | — | 5 | 18 | 5 | 4 | 30 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 3 | 11 | 2 | 2 | 16 |
| Appendicitis | D001064 | EFO_0007149 | K37 | 1 | 1 | — | 1 | 8 | 11 |
| Intraabdominal infections | D059413 | — | — | — | 2 | 6 | 2 | — | 10 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 2 | 3 | 1 | 1 | 7 |
| Acute disease | D000208 | — | — | — | 1 | — | 2 | 3 | 6 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | 1 | 1 | 2 | 5 |
| Klebsiella infections | D007710 | EFO_1001353 | — | — | 1 | 1 | 2 | 1 | 4 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 2 | — | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 1 | 2 | — | 3 | 6 |
| Bacterial infections | D001424 | — | A49 | 1 | — | 1 | — | 2 | 4 |
| Surgical wound infection | D013530 | — | — | — | 1 | 3 | — | — | 3 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 2 | 1 | — | — | 3 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 2 | 2 | — | — | 3 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | 3 | — | — | 3 |
| Gonorrhea | D006069 | DOID_7551 | A54 | — | — | 1 | — | — | 1 |
| Healthcare-associated pneumonia | D000077299 | — | — | — | — | 1 | — | — | 1 |
| Kidney transplantation | D016030 | — | — | — | 1 | 1 | — | — | 1 |
| Abdominal injuries | D000007 | — | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 2 | — | — | — | 2 |
| Pelvic infection | D034161 | — | — | — | 1 | — | — | — | 1 |
| Pelvic inflammatory disease | D000292 | EFO_1001388 | N70-N77 | — | 1 | — | — | — | 1 |
| Staphylococcal infections | D013203 | — | A49.01 | — | 1 | — | — | — | 1 |
| Endocarditis | D004696 | HP_0100584 | — | — | 1 | — | — | — | 1 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometritis | D004716 | EFO_1001312 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inappropriate prescribing | D057970 | — | — | — | — | — | — | 1 | 1 |
| Drug therapy | D004358 | — | — | — | — | — | — | 1 | 1 |
| Appendectomy | D001062 | — | — | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Gallstones | D042882 | EFO_0004210 | — | — | — | — | — | 1 | 1 |
| Acute cholecystitis | D041881 | EFO_1001289 | K81.0 | — | — | — | — | 1 | 1 |
| Cholecystitis | D002764 | HP_0001082 | K81 | — | — | — | — | 1 | 1 |
| Acalculous cholecystitis | D042101 | EFO_1000790 | — | — | — | — | — | 1 | 1 |
| Surgical amputation | D000671 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ertapenem |
| INN | ertapenem |
| Description | Ertapenem is meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract. It has a role as an antibacterial drug. It is a carbapenemcarboxylic acid and a pyrrolidinecarboxamide. It is a conjugate acid of an ertapenem(1-). |
| Classification | Small molecule |
| Drug class | antibacterial antibiotics, carbapenem derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 153832-46-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1359 |
| ChEBI ID | 404903 |
| PubChem CID | 150610 |
| DrugBank | DB00303 |
| UNII ID | G32F6EID2H (ChemIDplus, GSRS) |
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Invanz – Merck & Co
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Safety
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5,013 adverse events reported
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