Ergotamine
Caffeine / Ergotamine, Ergomar, Migergot (ergotamine) is a small molecule pharmaceutical. Ergotamine was first approved as Cafergot on 1982-01-01. It is used to treat cluster headache and migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 6.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Combinations
Migergot (discontinued: Cafergot, Ergotamine caffeine, Wigraine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ergotamine tartrate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ergomar | ANDA | 2025-02-25 |
| ergotamine | ANDA | 2013-04-10 |
| ergotamine tartrate and caffeine | ANDA | 2025-03-27 |
| migergot | ANDA | 2022-11-29 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| migraine disorders | EFO_0003821 | D008881 | G43 |
| cluster headache | — | D003027 | G44.00 |
| fatigue | — | D005221 | R53.83 |
| apnea | — | D001049 | R06.81 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1110 | Injection, dihydroergotamine mesylate, per 1 mg |
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 3 | 1 | 4 | 2 | 1 | 11 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 3 | 2 | 1 | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | 2 | 2 | — | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | 1 | 1 | — | 4 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | 2 | 1 | — | 4 |
| Headache | D006261 | — | R51 | 1 | — | 2 | 1 | — | 4 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 1 | — | 2 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | — | 1 | — | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | 1 | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | 2 | — | 3 | — | — | 5 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | 2 | — | 3 | — | — | 5 |
| Peripartum cardiomyopathy | D000099088 | — | O90.3 | — | 1 | 1 | — | — | 2 |
| Ischemic stroke | D000083242 | — | — | 1 | 2 | 1 | — | — | 2 |
| Hyperprolactinemia | D006966 | — | E22.1 | — | — | 2 | — | — | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | 1 | — | 1 | 2 |
| Vascular dementia | D015140 | — | F01 | — | 2 | 1 | — | — | 2 |
| Tension-type headache | D018781 | — | G44.2 | — | — | 1 | — | — | 1 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | — | 6 |
| Syndrome | D013577 | — | — | — | 3 | — | — | — | 3 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | — | 2 | — | — | — | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | 1 | — | — | — | 1 |
| Cerebral hemorrhage | D002543 | — | — | 1 | 1 | — | — | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 1 | 1 | — | — | — | 1 |
| Subdural hematoma | D006408 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Anorexia | D000855 | — | R63.0 | 1 | — | — | — | — | 1 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | 1 | — | — | — | — | 1 |
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | — | — | — | — | 1 | 1 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | — | — | — | 1 | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 1 | 1 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | — | — | — | — | 1 | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | — | 1 | 1 |
| Fibrosis | D005355 | — | — | — | — | — | — | 1 | 1 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 1 | 1 |
| Pituitary neoplasms | D010911 | — | — | — | — | — | — | 1 | 1 |
| Prolactinoma | D015175 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ergotamine |
| INN | ergotamine |
| Description | Ergotamine is a peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. It has a role as a non-narcotic analgesic, a vasoconstrictor agent, a serotonergic agonist, an alpha-adrenergic agonist, a mycotoxin and an oxytocic. It is a conjugate base of an ergotamine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 113-15-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL442 |
| ChEBI ID | 64318 |
| PubChem CID | 8223 |
| DrugBank | DB00696 |
| UNII ID | PR834Q503T (ChemIDplus, GSRS) |
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Migergot – Horizon Therapeutics Public
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Estimated US medical usage
Ergotamine
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Ergotamine
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Phenobarbital
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Atropa belladonna
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Ergomar, Ergotamine, Ergotamine tartrate and caffeine, Migergot
Adverse Events
Top Adverse Reactions
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1,662 adverse events reported
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