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Drug ReportsErgotamine
Ergotamine
Caffeine / Ergotamine, Ergomar, Migergot (ergotamine) is a small molecule pharmaceutical. Ergotamine was first approved as Cafergot on 1982-01-01. It is used to treat cluster headache and migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 6.
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Commercial
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Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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FDA approval date
EMA approval date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Combinations
Ergotamine caffeine, Migergot (discontinued: Cafergot, Ergotamine caffeine, Wigraine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ergotamine tartrate
Tradename
Company
Number
Date
Products
MEDIHALER ERGOTAMINE3MN-012102 DISCN1982-01-01
1 products
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Caffeine
+
Ergotamine tartrate
Tradename
Company
Number
Date
Products
CAFERGOTNovartisN-009000 DISCN1982-01-01
1 products, RLD
CAFERGOTNovartisN-006620 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
ergomarANDA2025-02-25
ergotamineANDA2013-04-10
ergotamine tartrate and caffeineANDA2025-03-27
migergotANDA2022-11-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
migraine disordersEFO_0003821D008881G43
cluster headache—D003027G44.00
fatigue—D005221R53.83
apnea—D001049R06.81
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CA: Ergot alkaloids, antimigraine
— N02CA02: Ergotamine
— N02CA52: Ergotamine, combinations excl. psycholeptics
— N02CA72: Ergotamine, combinations with psycholeptics
HCPCS
Code
Description
J1110
Injection, dihydroergotamine mesylate, per 1 mg
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———31———3
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameErgotamine
INNergotamine
Description
Ergotamine is a peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. It has a role as a non-narcotic analgesic, a vasoconstrictor agent, a serotonergic agonist, an alpha-adrenergic agonist, a mycotoxin and an oxytocic. It is a conjugate base of an ergotamine(1+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21
Identifiers
PDB—
CAS-ID113-15-5
RxCUI—
ChEMBL IDCHEMBL442
ChEBI ID64318
PubChem CID8223
DrugBankDB00696
UNII IDPR834Q503T (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Migergot – Horizon Therapeutics Public
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Estimated US medical usage
Ergotamine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Ergotamine
+
Phenobarbital
+
Atropa belladonna
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,328 documents
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Safety
Black-box Warning
Black-box warning for: Ergomar, Ergotamine, Ergotamine tartrate and caffeine, Migergot
Adverse Events
Top Adverse Reactions
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1,662 adverse events reported
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