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Drug ReportsEptifibatide
Integrilin(eptifibatide)
Eptifibatide, Integrilin (eptifibatide) is a protein pharmaceutical. Eptifibatide was first approved as Integrilin on 1998-05-18. It is used to treat coronary disease, myocardial infarction, and unstable angina in the USA. It has been approved in Europe to treat myocardial infarction and unstable angina.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Eptifibatide (discontinued: Eptifibatide, Integrilin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Eptifibatide
Tradename
Company
Number
Date
Products
INTEGRILINMerck & CoN-020718 DISCN1998-05-18
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
eptifibatideANDA2024-12-19
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B01: Antithrombotic agents
B01A: Antithrombotic agents
B01AC: Platelet aggregation inhibitors excl. heparin
B01AC16: Eptifibatide
HCPCS
Code
Description
G9531
Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar
J1327
Injection, eptifibatide, 5 mg
Clinical
No data
Drug
General
Drug common nameEptifibatide
INNeptifibatide
Description
Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a disintegrin protein (P22827) found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.
Classification
Protein
Drug classpeptides: platelet aggregation inhibitor (GPIIb/IIIa receptor antagonist)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NCCCC[C@@H]1NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O
Identifiers
PDB
CAS-ID188627-80-7
RxCUI
ChEMBL IDCHEMBL1174
ChEBI ID291902
PubChem CID123610
DrugBankDB00063
UNII IDNA8320J834 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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