Enzastaurin
Enzastaurin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against protein kinase C beta type. In addition, it is known to target protein kinase C alpha type, protein kinase C delta type, and protein kinase C gamma type.
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Commercial
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Clinical
Clinical Trials
51 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 2 | 6 | 2 | — | — | 10 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 3 | 2 | — | — | 6 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 2 | 1 | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 2 | 1 | — | — | 3 |
| B-cell lymphoma | D016393 | — | — | — | 1 | 1 | — | — | 2 |
| Ehlers-danlos syndrome | D004535 | Orphanet_98249 | Q79.6 | — | — | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
| Type iv ehlers-danlos syndrome | D000094623 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 5 | 3 | — | — | — | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 7 | — | — | — | 7 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 5 | — | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 4 | — | — | — | 4 |
| Glioma | D005910 | EFO_0000520 | — | 3 | 1 | — | — | — | 4 |
| Prostatic neoplasms | D011471 | — | C61 | — | 3 | — | — | — | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 3 | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | 2 | — | — | — | — | 2 |
| Ependymoma | D004806 | — | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | — | — | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
| Nervous system neoplasms | D009423 | — | — | 1 | — | — | — | — | 1 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Enzastaurin |
| INN | enzastaurin |
| Description | 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione is a member of indoles and a member of maleimides. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 170364-57-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL300138 |
| ChEBI ID | — |
| PubChem CID | 176167 |
| DrugBank | — |
| UNII ID | UC96G28EQF (ChemIDplus, GSRS) |
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Safety
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261 adverse events reported
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