Entospletinib
Entospletinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase SYK.
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 5 | 1 | — | — | 7 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | 2 | 1 | — | — | 4 |
| Myeloid leukemia | D007951 | — | C92 | 3 | 2 | 1 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 4 | — | — | — | 5 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 3 | — | — | — | 4 |
| Lymphoma | D008223 | — | C85.9 | 2 | 4 | — | — | — | 4 |
| Hematologic neoplasms | D019337 | — | — | 1 | 2 | — | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 3 | — | — | — | 3 |
| Mantle-cell lymphoma | D020522 | — | — | 1 | 3 | — | — | — | 3 |
| B-cell lymphoma | D016393 | — | — | 2 | 1 | — | — | — | 2 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 2 | — | — | — | 2 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 2 | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | 1 | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Entospletinib |
| INN | entospletinib |
| Description | Entospletinib is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences. It is an inhibitor of spleen tyrosine kinase (Syk). It has entered clinical trials for acute myeloid leukaemia (AML), chronic lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), graft-versus-host disease (GvHD), hematological malignancies, mantle cell lymphoma (MCL), and non-Hodgkin lymphoma (NHL).
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| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 1229208-44-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3265032 |
| ChEBI ID | — |
| PubChem CID | 59473233 |
| DrugBank | DB12121 |
| UNII ID | 6I3O3W6O3B (ChemIDplus, GSRS) |
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Safety
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15 adverse events reported
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