Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myeloid leukemia acute | D015470 | — | C92.0 | 3 | 2 | 1 | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 4 | — | — | — | 5 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 3 | — | — | — | 3 |
Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | 3 | — | — | — | 3 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 2 | — | — | — | 2 |
Follicular lymphoma | D008224 | — | C82 | 1 | 2 | — | — | — | 2 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 1 | — | — | — | 1 |
Anemia | D000740 | HP_0001903 | D64.9 | 1 | 1 | — | — | — | 1 |
Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 1 | 1 | — | — | — | 1 |
Hairy cell leukemia | D007943 | — | C91.4 | 1 | 1 | — | — | — | 1 |
Reactive arthritis | D016918 | EFO_0007460 | M02.3 | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Entospletinib |
INN | entospletinib |
Description | Entospletinib is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences. It is an inhibitor of spleen tyrosine kinase (Syk). It has entered clinical trials for acute myeloid leukaemia (AML), chronic lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), graft-versus-host disease (GvHD), hematological malignancies, mantle cell lymphoma (MCL), and non-Hodgkin lymphoma (NHL).
|
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1 |
PDB | — |
CAS-ID | 1229208-44-9 |
RxCUI | — |
ChEMBL ID | CHEMBL3265032 |
ChEBI ID | — |
PubChem CID | 59473233 |
DrugBank | DB12121 |
UNII ID | 6I3O3W6O3B (ChemIDplus, GSRS) |