Tradename | Company | Number | Date | Products |
---|---|---|---|---|
BARACLUDE | Bristol Myers Squibb | N-021797 RX | 2005-03-29 | 2 products, RLD, RS |
BARACLUDE | Bristol Myers Squibb | N-021798 RX | 2005-03-29 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
baraclude | New Drug Application | 2024-05-09 |
entecavir | ANDA | 2025-06-08 |
entecavir entecavir | ANDA | 2025-01-09 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
hepatitis b | — | D006509 | — |
chronic hepatitis b | EFO_0004239 | D019694 | B18.1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 3 | 2 | — | — | — | 4 |
Hepatitis b | D006509 | — | — | 2 | 1 | — | — | — | 2 |
Hepatitis | D006505 | — | K75.9 | 2 | 1 | — | — | — | 2 |
Hepatitis a | D006506 | EFO_0007305 | B15 | 2 | 1 | — | — | — | 2 |
Drug common name | Entecavir |
INN | entecavir |
Description | Entecavir (anhydrous) is guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. It has a role as an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral drug. It is a member of 2-aminopurines, an oxopurine, a primary alcohol and a secondary alcohol. |
Classification | Small molecule |
Drug class | antivirals: carbocyclic nucleosides |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | C=C1[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@H](O)[C@H]1CO |
PDB | — |
CAS-ID | 142217-69-4 |
RxCUI | — |
ChEMBL ID | CHEMBL713 |
ChEBI ID | 473990 |
PubChem CID | 135398508 |
DrugBank | DB00442 |
UNII ID | NNU2O4609D (ChemIDplus, GSRS) |