Enoblituzumab
Enoblituzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against CD276 antigen.
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w... | Biologic Licensing Application | 2011-03-11 |
| ad incontinence support | C200263 | 2025-03-07 |
| avance incontinence care | C200263 | 2026-01-12 |
| bioelements, inc. | OTC monograph not final | 2012-01-17 |
| ca-rezz - long term care - incontinent cleanser | C200263 | 2025-10-22 |
| ca-rezz - norisc - incontinent wash | C200263 | 2025-10-22 |
| center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al... | Biologic Licensing Application | 2009-06-12 |
| chain drug marketing association, inc. | C200263 | 2025-08-22 |
| crooked creek distillery inc hand sanitizer | OTC monograph not final | 2020-03-25 |
| cvs pharmacy,inc. | C200263 | 2025-12-04 |
Show 58 more
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Clinical
Clinical Trials
2920 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 150 | 2 | 2 | 4 | 70 | 227 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 40 | — | — | 1 | 11 | 52 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 7 | 6 | 1 | 2 | 38 | 51 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 7 | 4 | 2 | 3 | 34 | 49 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 4 | 2 | 4 | 35 | 45 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 5 | 9 | 7 | 2 | 25 | 45 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 7 | 4 | 1 | 32 | 45 |
| Hypertension | D006973 | EFO_0000537 | I10 | 12 | 6 | 5 | 1 | 20 | 42 |
| Covid-19 | D000086382 | — | U07.1 | 2 | 8 | 4 | 5 | 24 | 40 |
| Postoperative pain | D010149 | — | G89.18 | 2 | 1 | — | 6 | 31 | 40 |
Show 240 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 6 | 1 | — | 34 | 42 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 15 | — | 6 | — | 5 | 26 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 2 | 2 | 4 | — | 19 | 26 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 2 | 4 | 7 | — | 13 | 25 |
| Prostatic neoplasms | D011471 | — | C61 | 7 | 10 | 1 | — | 9 | 24 |
| Carcinoma | D002277 | — | C80.0 | 4 | 9 | 3 | — | 8 | 23 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 5 | 1 | 1 | — | 12 | 18 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 6 | 4 | 1 | — | 6 | 15 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 3 | 2 | — | 8 | 14 |
| Keratoconus | D007640 | EFO_0004223 | H18.6 | — | 2 | 2 | — | 11 | 14 |
Show 162 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 5 | — | — | 10 | 17 |
| Sclerosis | D012598 | — | — | 4 | 2 | — | — | 11 | 16 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 4 | — | — | 11 | 15 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 4 | 1 | — | — | 9 | 14 |
| Back pain | D001416 | — | M54 | — | 2 | — | — | 12 | 14 |
| Hiv | D006678 | — | O98.7 | 3 | 2 | — | — | 9 | 13 |
| Lymphoma | D008223 | — | C85.9 | 8 | 3 | — | — | 3 | 13 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | 12 | 13 |
| Brain injuries | D001930 | — | S06.9 | — | 1 | — | — | 11 | 12 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | 11 | 12 |
Show 220 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease | D004194 | EFO_0000408 | R69 | 3 | — | — | — | 7 | 10 |
| Hypoxia | D000860 | — | R09.02 | 1 | — | — | — | 9 | 10 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 4 | — | — | — | 5 | 9 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 2 | — | — | — | 6 | 8 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | — | 7 | 8 |
| Headache | D006261 | — | R51 | 1 | — | — | — | 6 | 7 |
| Paresis | D010291 | — | — | 1 | — | — | — | 6 | 7 |
| Muscle weakness | D018908 | — | — | 1 | — | — | — | 6 | 7 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | — | — | — | 3 | 6 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 1 | — | — | — | 5 | 6 |
Show 127 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cutis laxa | D003483 | — | Q82.8 | — | — | — | — | 19 | 19 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | — | — | — | 11 | 11 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | — | — | 9 | 9 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | — | 8 | 8 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 8 | 8 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 7 | 7 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 7 | 7 |
| Astigmatism | D001251 | EFO_0004222 | H52.2 | — | — | — | — | 7 | 7 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 7 | 7 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 6 | 6 |
Show 737 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Enoblituzumab |
| INN | enoblituzumab |
| Description | Enoblituzumab is a monoclonal antibody designed for the treatment of cancer. Formerly known as MGA271, the drug is a humanized IgG1κ monoclonal antibody recognizing human B7-H3, a member of the B7 family of immune regulators.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545373 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | M6030H73N9 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., Center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al..., Xeomin
Adverse Events
Top Adverse Reactions
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1,125 adverse events reported
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