Enoblituzumab
Enoblituzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against CD276 antigen.
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Drug Products
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New Drug Application (NDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w... | Biologic Licensing Application | 2011-03-11 |
| avance incontinence care | C200263 | 2024-05-11 |
| bioelements, inc. | OTC monograph not final | 2012-01-17 |
| ca-rezz - long term care - incontinent cleanser | C200263 | 2023-10-03 |
| ca-rezz - norisc - incontinent wash | C200263 | 2023-10-03 |
| center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al... | Biologic Licensing Application | 2009-06-12 |
| chain drug marketing association, inc. | C200263 | 2024-05-21 |
| crooked creek distillery inc hand sanitizer | OTC monograph not final | 2020-03-25 |
| cvs pharmacy,inc. | C200263 | 2024-08-16 |
| dr. butler soothing incontinence | OTC monograph final | 2021-11-23 |
Show 54 more
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Clinical
Clinical Trials
2711 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 148 | 2 | 1 | 4 | 68 | 222 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 44 | — | — | 1 | 11 | 56 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 5 | 9 | 7 | 3 | 24 | 45 |
| Wounds and injuries | D014947 | — | T14.8 | 7 | 7 | 2 | 4 | 29 | 45 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 7 | 4 | 1 | 32 | 45 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 6 | 5 | 1 | 4 | 30 | 45 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 6 | 5 | 1 | 2 | 32 | 43 |
| Syndrome | D013577 | — | — | 1 | 5 | 5 | 3 | 30 | 43 |
| Hypertension | D006973 | EFO_0000537 | I10 | 11 | 6 | 6 | 1 | 20 | 42 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 4 | 2 | 4 | 31 | 41 |
Show 251 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 10 | 11 | 2 | — | 8 | 28 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 2 | 4 | — | 19 | 25 |
| Prostatic neoplasms | D011471 | — | C61 | 7 | 10 | 1 | — | 9 | 24 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 14 | — | 6 | — | 4 | 24 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 5 | 1 | 1 | — | 11 | 17 |
| Sclerosis | D012598 | — | — | 4 | 2 | 1 | — | 11 | 17 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | — | 1 | — | 14 | 16 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 6 | 4 | 1 | — | 5 | 14 |
| Keratoconus | D007640 | EFO_0004223 | H18.6 | — | 2 | 2 | — | 11 | 14 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 3 | 1 | — | 8 | 13 |
Show 155 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 4 | — | — | 33 | 38 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 4 | — | — | 10 | 16 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 4 | — | — | 11 | 15 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | 13 | 14 |
| Brain injuries | D001930 | — | S06.9 | — | 2 | — | — | 11 | 13 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 3 | 2 | — | — | 8 | 13 |
| Hiv | D006678 | — | — | 3 | 2 | — | — | 8 | 12 |
| Leukemia | D007938 | — | C95 | 5 | 4 | — | — | 2 | 11 |
| Lymphoma | D008223 | — | C85.9 | 7 | 3 | — | — | 2 | 11 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 2 | — | — | 9 | 11 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease | D004194 | EFO_0000408 | R69 | 3 | — | — | — | 6 | 9 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 4 | — | — | — | 5 | 9 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | 7 | 8 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 2 | — | — | — | 6 | 8 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 3 | — | — | — | 4 | 7 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 2 | — | — | — | 5 | 7 |
| Muscle weakness | D018908 | HP_0001324 | — | 1 | — | — | — | 6 | 7 |
| Paresis | D010291 | HP_0001269 | — | 1 | — | — | — | 5 | 6 |
| Aortic dissection | D000784 | — | I71.0 | 1 | — | — | — | 5 | 6 |
| Fasting | D005215 | EFO_0002756 | — | 5 | — | — | — | — | 5 |
Show 117 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cutis laxa | D003483 | — | Q82.8 | — | — | — | — | 18 | 18 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | — | — | — | 12 | 12 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | — | 8 | 8 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | — | 8 | 8 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 8 | 8 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 7 | 7 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 6 | 6 |
| Respiration disorders | D012120 | — | J00-J99 | — | — | — | — | 6 | 6 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | — | — | — | 6 | 6 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 5 | 5 |
Show 667 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Enoblituzumab |
| INN | enoblituzumab |
| Description | Enoblituzumab is a monoclonal antibody designed for the treatment of cancer. Formerly known as MGA271, the drug is a humanized IgG1κ monoclonal antibody recognizing human B7-H3, a member of the B7 family of immune regulators.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545373 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | M6030H73N9 (ChemIDplus, GSRS) |
Target
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., Center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al..., Xeomin
Adverse Events
Top Adverse Reactions
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1,145 adverse events reported
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