Enoblituzumab
Enoblituzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against CD276 antigen.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
FDA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
2775 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DyspareuniaD004414—N94.1——1——1
AtrophyD001284————1——1
Acne vulgarisD000152EFO_0003894L70——1——1
AsthmaD001249EFO_0000270J45——1——1
Lice infestationsD010373—B85.2——1——1
PediculusD010374————1——1
PsoriasisD011565EFO_0000676L40——1——1
Indications Phases 2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEnoblituzumab
INNenoblituzumab
Description
Enoblituzumab is a monoclonal antibody designed for the treatment of cancer. Formerly known as MGA271, the drug is a humanized IgG1κ monoclonal antibody recognizing human B7-H3, a member of the B7 family of immune regulators.
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Classification
Antibody
Drug classmonoclonal antibodies
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Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL3545373
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDM6030H73N9 (ChemIDplus, GSRS)
Target
Agency Approved
CD276
CD276
Organism
Homo sapiens
Gene name
CD276
Gene synonyms
B7H3
NCBI Gene ID
Protein name
CD276 antigen
Protein synonyms
4Ig-B7-H3, B7 homolog 3, B7-H3, CD276, Costimulatory molecule
Uniprot ID
Mouse ortholog
Cd276 (102657)
CD276 antigen (Q8VE98)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,005,859 documents
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., Center-al - acacia longifolia pollen center-al - acer negundo pollen center-al - acer saccharum pollen center-al - agrostis gigantea center-al - al..., Xeomin
Adverse Events
Top Adverse Reactions
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3 adverse events reported
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