Enclomiphene
Enclomiphene is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| derofen miel | OTC monograph final | 2021-04-06 |
Indications
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Agency Specific
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Clinical
Clinical Trials
256 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | HP_0000789 | — | 9 | 16 | 25 | 40 | 39 | 118 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 7 | 13 | 23 | 25 | 34 | 96 |
| Syndrome | D013577 | — | — | 1 | 7 | 12 | 16 | 24 | 58 |
| Anovulation | D000858 | — | — | 1 | 5 | 5 | 6 | 7 | 23 |
| Female infertility | D007247 | EFO_0008560 | N97 | 1 | 3 | 5 | 6 | 9 | 21 |
| Ovulation induction | D010062 | — | — | — | — | 3 | 4 | 2 | 9 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 3 | 2 | 1 | 7 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | 1 | 3 | 4 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | 2 | — | 1 | 1 | 4 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | 2 | — | 1 | — | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypogonadism | D007006 | HP_0000044 | E23.0 | 3 | 13 | 9 | — | 2 | 27 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 7 | — | — | 11 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | 2 | 2 | — | 1 | 4 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | 1 | — | 1 | 3 |
| Hyperandrogenism | D017588 | — | — | — | 2 | 1 | — | — | 3 |
| Overweight | D050177 | — | E66.3 | — | — | 2 | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 1 | — | 1 | — | — | 2 |
| Leiomyoma | D007889 | HP_0000131 | D25 | 1 | — | 1 | — | — | 2 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | — | — | 1 | — | 1 | 2 |
| Sarcoma | D012509 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | 2 | — | — | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | — | — | — | 1 |
| Ganglioneuroblastoma | D018305 | — | — | — | 1 | — | — | — | 1 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | 1 | 1 | — | — | — | 1 |
| Gonadal disorders | D006058 | — | — | 1 | 1 | — | — | — | 1 |
| Uterine hemorrhage | D014592 | — | — | — | 1 | — | — | — | 1 |
| Hyperprolactinemia | D006966 | HP_0000870 | E22.1 | — | 1 | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy rate | D018873 | — | — | 1 | — | — | — | 2 | 3 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | 1 | — | — | — | 1 | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperthermia | D000084462 | — | — | — | — | — | — | 4 | 4 |
| Hyperinsulinism | D006946 | HP_0000842 | E16.1 | — | — | — | — | 2 | 2 |
| Thrombosis | D013927 | — | — | — | — | — | — | 1 | 1 |
| Ectopic pregnancy | D011271 | — | O00 | — | — | — | — | 1 | 1 |
| Hysteroscopy | D015907 | — | — | — | — | — | — | 1 | 1 |
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 1 | 1 |
| Affect | D000339 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 1 | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Enclomiphene |
| INN | enclomifene |
| Description | Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene. |
| Classification | Small molecule |
| Drug class | Selective estrogen receptor modulator; Progonadotropin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 911-45-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL954 |
| ChEBI ID | — |
| PubChem CID | 1548953 |
| DrugBank | DB00882 |
| UNII ID | R6D2UI4FLS (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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155 adverse events reported
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