Encenicline
Encenicline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against neuronal acetylcholine receptor subunit alpha-7.
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Commercial
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 3 | 4 | — | — | 8 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 1 | 3 | — | — | 5 |
| Dementia | D003704 | EFO_0003862 | F03 | — | 1 | 3 | — | — | 4 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | 3 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | 2 | 2 | — | — | — | 4 |
| Nervous system diseases | D009422 | — | G00-G99 | 2 | 2 | — | — | — | 4 |
| Cognition | D003071 | EFO_0003925 | — | — | 3 | — | — | — | 3 |
| Tobacco use disorder | D014029 | — | F17 | — | 1 | — | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychotic disorders | D011618 | — | F20.81 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Encenicline |
| INN | encenicline |
| Description | Encenicline (INN, USAN, code names EVP-6124, MT-4666) is a selective partial agonist of the α7 nicotinic receptor. It was in phase III clinical trials for the treatment of cognitive impairment in schizophrenia, but failed to meet the study endpoints in 2016.
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| Classification | Small molecule |
| Drug class | nicotinic acetylcholine receptor partial agonists/agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(Cl)c2s1 |
Identifiers
| PDB | — |
| CAS-ID | 1275596-71-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2151572 |
| ChEBI ID | — |
| PubChem CID | 46196517 |
| DrugBank | — |
| UNII ID | 5FI5376A0X (ChemIDplus, GSRS) |
Target
Agency Approved
CHRNA7
CHRNA7
Organism
Homo sapiens
Gene name
CHRNA7
Gene synonyms
NACHRA7
NCBI Gene ID
Protein name
neuronal acetylcholine receptor subunit alpha-7
Protein synonyms
a7 nicotinic acetylcholine receptor, alpha 7 neuronal nicotinic acetylcholine receptor, alpha-7 nicotinic cholinergic receptor subunit, cholinergic receptor, nicotinic alpha 7, cholinergic receptor, nicotinic, alpha 7 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 7, neuronal acetylcholine receptor protein, alpha-7 chain
Uniprot ID
Mouse ortholog
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Alternate
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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