Enalaprilat
Vasotec (enalaprilat) is a small molecule pharmaceutical. Enalaprilat was first approved as Vasotec on 1988-02-09. It is used to treat bartter syndrome, diabetic nephropathies, edema, heart failure, and left ventricular dysfunction amongst others in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Trade Name
FDA
EMA
Enalaprilat (discontinued: Enalaprilat, Vasotec)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Enalaprilat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VASOTEC | Bausch Health Companies | N-019309 DISCN | 1988-02-09 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| enalaprilat | ANDA | 2024-06-07 |
| vasotec | New Drug Application | 2020-12-01 |
Indications
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Agency Specific
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Clinical
Clinical Trials
166 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 3 | 9 | 13 | 18 | 12 | 52 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 6 | 16 | 14 | 3 | 36 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 5 | 2 | 8 | 7 | 20 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 4 | 4 | 2 | 13 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 4 | 4 | 1 | 3 | 10 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 3 | 5 | 1 | 2 | 9 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | 4 | 2 | 8 |
| Essential hypertension | D000075222 | — | I10 | 1 | 3 | 1 | 3 | 1 | 8 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 1 | — | 4 | 2 | 7 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 2 | 1 | 2 | 3 | 7 |
Show 41 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | — | 4 | 6 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | 1 | — | 2 | 4 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 2 | 4 | — | — | 4 |
| Coronary disease | D003327 | — | — | — | 1 | 2 | — | 1 | 3 |
| Systolic murmurs | D054160 | — | R01.1 | — | 1 | 1 | — | 1 | 3 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 1 | — | — | 2 |
| Nephritis | D009393 | — | N05 | — | 1 | 1 | — | 1 | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | 1 | 2 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | 1 | 2 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | 1 | — | — | 2 |
Show 26 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 2 | — | — | 2 | 4 |
| Cerebral hemorrhage | D002543 | — | — | — | 2 | — | — | 2 | 4 |
| Glomerulonephritis | D005921 | HP_0000099 | N05 | — | 2 | — | — | 1 | 3 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 2 | — | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | — | 1 | — | — | — | 1 |
| Membranoproliferative glomerulonephritis | D015432 | — | — | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Isolated systolic hypertension | D000092244 | — | — | — | 1 | — | — | — | 1 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 1 | — | — | — | — | 1 |
| Kidney transplantation | D016030 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 4 | 4 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | — | — | 2 | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 2 | 2 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Fabry disease | D000795 | Orphanet_324 | E75.21 | — | — | — | — | 1 | 1 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | — | — | 1 | 1 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 1 | 1 |
| Angioedema | D000799 | EFO_0005532 | T78.3 | — | — | — | — | 1 | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | — | 1 | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 1 | 1 |
Show 16 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Enalaprilat |
| INN | enalaprilat |
| Description | Enalaprilat (anhydrous) is enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is a dicarboxylic acid and a dipeptide. |
| Classification | Small molecule |
| Drug class | narcotic agonists/antagonists (normorphine type); antihypertensives (ACE inhibitors): antihypertensives (ACE inhibitors), diacid analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 76420-72-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL577 |
| ChEBI ID | 4786 |
| PubChem CID | — |
| DrugBank | DB00584 |
| UNII ID | Q508Q118JM (ChemIDplus, GSRS) |
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Enalaprilat, Vasotec
Adverse Events
Top Adverse Reactions
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770 adverse events reported
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