Vasotec, Aqumeldi(enalapril)
Aqumeldi, Enalapril, Epaned, Lexxel, Teczem, Vaseretic, Vasotec (enalapril) is a small molecule pharmaceutical. Enalapril was first approved as Vasotec on 1985-12-24. It is used to treat bartter syndrome, diabetic nephropathies, edema, heart failure, and left ventricular dysfunction amongst others in the USA. It has been approved in Europe to treat heart failure. The pharmaceutical is active against angiotensin-converting enzyme.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Epaned, Vasotec (generic drugs available since 2000-08-22)
CombinationsVaseretic (generic drugs available since 2000-08-22, discontinued: Lexxel, Teczem)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diltiazem malate
+
Enalapril maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TECZEM | Bausch Health Companies | N-020507 DISCN | 1996-10-04 | 1 products |
Hide discontinued
Enalapril maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EPANED | Azurity | N-208686 RX | 2016-09-20 | 1 products, RLD, RS |
| VASOTEC | Bausch Health Companies | N-018998 RX | 1985-12-24 | 4 products, RLD, RS |
Show 1 discontinued
Enalapril maleate
+
Felodipine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LEXXEL | AstraZeneca | N-020668 DISCN | 1996-12-27 | 2 products |
Hide discontinued
Enalapril maleate
+
Hydrochlorothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VASERETIC | Bausch Health Companies | N-019221 RX | 1986-10-31 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| enalapril maleate | ANDA | 2024-01-18 |
| enalapril maleate and hydrochlorothiazide | ANDA | 2023-12-08 |
| enalapril maleate oral solution | ANDA | 2023-12-27 |
| enalaprilat | ANDA | 2024-01-04 |
| epaned | New Drug Application | 2020-07-27 |
| vaseretic | New Drug Application | 2020-08-31 |
| vasotec | New Drug Application | 2018-11-12 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Enalapril Maleate, Epaned, Azurity | |||
| 9669008 | 2036-03-25 | DP | |
| 9808442 | 2036-03-25 | U-3, U-71, U-185, U-1723, U-1892 | |
| 10039745 | 2036-03-25 | DP | |
| 10154987 | 2036-03-25 | U-3, U-71, U-185, U-1723, U-1892 | |
| 10772868 | 2036-03-25 | DP | |
| 10786482 | 2036-03-25 | DP | |
| 11040023 | 2036-03-25 | DP | |
| 11141405 | 2036-03-25 | DP | |
| 11173141 | 2036-03-25 | DP | |
| Enalapril Maleate, Epaned Kit, Silvergate Pharms | |||
| 8568747 | 2032-11-06 | DP | |
| 8778366 | 2032-11-06 | U-3, U-71, U-185, U-1723, U-1892 | |
| 9855214 | 2032-11-06 | DP | |
| 9968553 | 2032-11-06 | U-3, U-71, U-185, U-1723, U-1892 | |
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA02: Enalapril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA02: Enalapril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB02: Enalapril and lercanidipine
— C09BB06: Enalapril and nitrendipine
HCPCS
No data
Clinical
Clinical Trials
164 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 6 | 13 | 14 | 9 | 42 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 5 | 15 | 13 | 2 | 33 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 4 | 3 | — | 10 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | 2 | 2 | 6 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 2 | 1 | 1 | 2 | 5 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 2 | 1 | — | 5 |
| Essential hypertension | D000075222 | — | I10 | 1 | 3 | — | 2 | — | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | 1 | 3 | 5 |
| Dilated cardiomyopathy | D002311 | HP_0001644 | I42.0 | — | 3 | 3 | 1 | — | 5 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 2 | 1 | 1 | 4 |
Show 26 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | — | 3 | 5 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 2 | 4 | — | — | 4 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | 1 | — | 2 | 3 |
| Coronary disease | D003327 | — | — | — | 1 | 2 | — | 1 | 3 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | 1 | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 1 | — | 1 | 2 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | — | 2 | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | 1 | — | — | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | 1 | — | — | 1 |
Show 10 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral hemorrhage | D002543 | — | — | — | 2 | — | — | 2 | 4 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 2 | — | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | — | 1 | — | — | — | 1 |
| Glomerulonephritis | D005921 | HP_0000099 | N05 | — | 1 | — | — | — | 1 |
| Membranoproliferative glomerulonephritis | D015432 | — | — | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Isolated systolic hypertension | D000092244 | — | — | — | 1 | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
Show 5 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 1 | 1 |
| Fabry disease | D000795 | Orphanet_324 | E75.21 | — | — | — | — | 1 | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | — | — | 1 | 1 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | — | — | 1 | 1 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 1 | 1 |
| Prehypertension | D058246 | — | — | — | — | — | — | 1 | 1 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 1 | 1 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Enalapril |
| INN | enalapril |
| Description | Enalapril is a dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration). It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, an antihypertensive agent and a geroprotector. It is a dicarboxylic acid monoester and a dipeptide. It is functionally related to an enalaprilat (anhydrous). |
| Classification | Small molecule |
| Drug class | narcotic agonists/antagonists (normorphine type); antihypertensives (ACE inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 75847-73-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL578 |
| ChEBI ID | 4784 |
| PubChem CID | 5388962 |
| DrugBank | DB00584 |
| UNII ID | 69PN84IO1A (ChemIDplus, GSRS) |
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Enalapril
+
Diltiazem
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Enalapril
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Enalapril
+
Felodipine
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Enalapril
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 19,703 documents
View more details
Safety
Black-box Warning
Black-box warning for: Enalapril maleate, Enalapril maleate and hydrochlorothiazide, Enalapril maleate oral solution, Enalaprilat, Epaned, Vaseretic, Vasotec
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
13,204 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use