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Drug ReportsEnalapril
Vasotec, Aqumeldi(enalapril)
Aqumeldi, Enalapril, Epaned, Lexxel, Teczem, Vaseretic, Vasotec (enalapril) is a small molecule pharmaceutical. Enalapril was first approved as Vasotec on 1985-12-24. It is used to treat bartter syndrome, diabetic nephropathies, edema, heart failure, and left ventricular dysfunction amongst others in the USA. It has been approved in Europe to treat heart failure. The pharmaceutical is active against angiotensin-converting enzyme.
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5D
1M
3M
6M
YTD
1Y
2Y
5Y
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EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
urogenital diseasesD000091642
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Enalapril, Epaned, Vasotec (discontinued: Enalapril, Epaned)
Combinations
Enalapril hydrochlorothiazide, Vaseretic (discontinued: Enalapril hydrochlorothiazide, Lexxel, Teczem)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Enalapril maleate
+
Felodipine
Tradename
Company
Number
Date
Products
LEXXELAstraZenecaN-020668 DISCN1996-12-27
2 products
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Enalapril maleate
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
VASERETICBausch Health CompaniesN-019221 RX1986-10-31
2 products, RLD, RS
Enalapril maleate
Tradename
Company
Number
Date
Products
EPANEDAzurityN-208686 RX2016-09-20
1 products, RLD, RS
VASOTECBausch Health CompaniesN-018998 RX1985-12-24
4 products, RLD, RS
Show 1 discontinued
Diltiazem malate
+
Enalapril maleate
Tradename
Company
Number
Date
Products
TECZEMBausch Health CompaniesN-020507 DISCN1996-10-04
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
enalapril maleateANDA2025-01-02
enalapril maleate and hydrochlorothiazideANDA2024-02-12
enalapril maleate oral solutionANDA2024-07-09
enalaprilatANDA2024-06-07
epanedNew Drug Application2020-07-27
vasereticNew Drug Application2020-08-31
vasotecNew Drug Application2020-12-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureHP_0001635D006333I50
diabetic nephropathiesEFO_0000401D003928—
left ventricular dysfunction—D018487—
rheumatoid arthritisEFO_0000685D001172M06.9
edemaHP_0000969D004487R60.9
malignant hypertensionEFO_1001031D006974—
bartter syndromeOrphanet_112D001477E26.81
hypertensionEFO_0000537D006973I10
nephrotic syndromeEFO_0004255D009404N04
variant angina pectoris—D000788I20.1
Show 4 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Enalapril Maleate, Epaned, Azurity
96690082036-03-25DP
98084422036-03-25U-3, U-71, U-185, U-1723, U-1892
100397452036-03-25DP
101549872036-03-25U-3, U-71, U-185, U-1723, U-1892
107728682036-03-25DP
107864822036-03-25DP
110400232036-03-25DP
111414052036-03-25DP
111731412036-03-25DP
Enalapril Maleate, Epaned Kit, Silvergate Pharms
85687472032-11-06DP
87783662032-11-06U-3, U-71, U-185, U-1723, U-1892
98552142032-11-06DP
99685532032-11-06U-3, U-71, U-185, U-1723, U-1892
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA02: Enalapril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA02: Enalapril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB02: Enalapril and lercanidipine
— C09BB06: Enalapril and nitrendipine
HCPCS
No data
Clinical
Clinical Trials
168 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333HP_0001635I50———1—1
Left ventricular dysfunctionD018487—————1—1
Ventricular dysfunctionD018754—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEnalapril
INNenalapril
Description
Enalapril is a dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration). It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, an antihypertensive agent and a geroprotector. It is a dicarboxylic acid monoester and a dipeptide. It is functionally related to an enalaprilat (anhydrous).
Classification
Small molecule
Drug classnarcotic agonists/antagonists (normorphine type); antihypertensives (ACE inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Identifiers
PDB—
CAS-ID75847-73-3
RxCUI—
ChEMBL IDCHEMBL578
ChEBI ID4784
PubChem CID5388962
DrugBankDB00584
UNII ID69PN84IO1A (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Enalapril
+
Diltiazem
Total medical expenditures per year (USD, in millions)
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Enalapril
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Enalapril
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Felodipine
Total medical expenditures per year (USD, in millions)
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Enalapril
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Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,675 documents
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Safety
Black-box Warning
Black-box warning for: Enalapril maleate, Enalapril maleate and hydrochlorothiazide, Enalapril maleate oral solution, Enalaprilat, Epaned, Vaseretic, Vasotec
Adverse Events
Top Adverse Reactions
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15,140 adverse events reported
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