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Drug ReportsEmtricitabine
Emtriva(emtricitabine)
/ Emtricitabine / Tenofovir Disoproxil, Atripla, Biktarvy, Complera, Descovy, Emtricitabine, Emtricitabine / Tenofovir Disoproxil, Emtriva, Eviplera, Genvoya, Odefsey, Stribild, Symtuza, Truvada (emtricitabine) is a small molecule pharmaceutical. Emtricitabine was first approved as Emtriva on 2003-07-02. It is used to treat HIV infections in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
Emtriva (generic drugs available since 2017-06-08)
Combinations
Atripla, Biktarvy, Complera, Descovy, Genvoya, Odefsey, Stribild, Symtuza, Truvada (generic drugs available since 2017-06-08)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bictegravir sodium
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
BIKTARVYGilead SciencesN-210251 RX2018-02-07
2 products, RLD, RS
Cobicistat
+
Darunavir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
SYMTUZAJohnson & JohnsonN-210455 RX2018-07-17
1 products, RLD, RS
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
GENVOYAGilead SciencesN-207561 RX2015-11-05
1 products, RLD, RS
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
STRIBILDGilead SciencesN-203100 RX2012-08-27
1 products, RLD, RS
Efavirenz
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
ATRIPLAGilead SciencesN-021937 RX2006-07-12
1 products, RLD, RS
Emtricitabine
Tradename
Company
Number
Date
Products
EMTRIVAGilead SciencesN-021500 RX2003-07-02
1 products, RLD, RS
EMTRIVAGilead SciencesN-021896 RX2005-09-28
1 products, RLD, RS
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
ODEFSEYGilead SciencesN-208351 RX2016-03-01
1 products, RLD, RS
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
COMPLERAGilead SciencesN-202123 RX2011-08-10
1 products, RLD, RS
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
DESCOVYGilead SciencesN-208215 RX2016-04-04
2 products, RLD, RS
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
TRUVADAGilead SciencesN-021752 RX2004-08-02
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
atriplaNew Drug Application2020-12-14
atripla accessExport only2020-12-14
biktarvyNew Drug Application2023-10-31
compleraNew Drug Application2020-12-09
complera accessExport only2020-12-10
descovyNew Drug Application2020-12-14
efavirenz, emtricitabine and tenofovir disoproxil fumarateANDA2023-12-28
emtricitabineANDA2023-11-21
emtricitabine and tenofovir disoproxil fumarateANDA2024-01-09
emtricitabine/tdfANDA2023-03-06
Show 8 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hiv infectionsEFO_0000764D015658B20
Agency Specific
FDA
EMA
Expiration
Code
EMTRICITABINE / TENOFOVIR ALAFENAMIDE FUMARATE, DESCOVY, GILEAD SCIENCES INC
2029-01-07ODE-457
2024-09-28ODE-284, ODE-285
BICTEGRAVIR SODIUM / EMTRICITABINE / TENOFOVIR ALAFENAMIDE FUMARATE, BIKTARVY, GILEAD SCIENCES INC
2028-10-07ODE-378
2026-06-18ODE-256
2024-02-24M-82
Patent Expiration
Patent
Expires
Flag
FDA Information
Cobicistat / Darunavir / Emtricitabine / Tenofovir Alafenamide Fumarate, Symtuza, Janssen Prods
107865182038-07-19U-2978
100397182032-10-06DP
81483742029-09-03DS, DPU-1279, U-2353, U-2364, U-2365, U-2766, U-2767, U-2768
77006452026-12-26DS, DP
85189872024-02-16DS, DP
Bictegravir Sodium / Emtricitabine / Tenofovir Alafenamide Fumarate, Biktarvy, Gilead Sciences Inc
105488462036-11-08DP
117448022036-11-08DP
97083422035-06-19DS, DP
103850672035-06-19U-257
92169962033-12-19DS, DP
97320922033-12-19DS, DP
87540652032-08-15DS, DPU-257, U-1259, U-1663, U-2352, U-2765
92967692032-08-15DS, DPU-257, U-1259, U-1663, U-2352, U-2765
73907912025-04-17DS, DP
Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Disoproxil Fumarate, Complera, Gilead Sciences Inc
108571022033-01-14DP
88413102025-12-09DPU-257
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Alafenamide Fumarate, Genvoya, Gilead Sciences Inc
86332192030-04-30DPU-257
98912392029-09-03DPU-257
76357042026-10-26DS, DPU-257
89811032026-10-26DS, DP
71762202026-08-27DS, DPU-257
Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate, Atripla, Gilead Sciences
85981852029-04-28DP
90181922026-06-13U-750, U-1170
95454142026-06-13DPU-750, U-1170
Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Alafenamide Fumarate, Odefsey, Gilead Sciences Inc
71258792025-04-21DS, DPU-257
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate, Stribild, Gilead Sciences Inc
85923972024-01-13DPU-248, U-257, U-541, U-750, U-1170
87162642024-01-13DPU-257
94570362024-01-13DPU-257
97441812024-01-13DPU-257
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
— J05AF09: Emtricitabine
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR03: Tenofovir disoproxil and emtricitabine
— J05AR06: Emtricitabine, tenofovir disoproxil and efavirenz
— J05AR08: Emtricitabine, tenofovir disoproxil and rilpivirine
— J05AR09: Emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat
— J05AR17: Emtricitabine and tenofovir alafenamide
— J05AR18: Emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat
— J05AR19: Emtricitabine, tenofovir alafenamide and rilpivirine
— J05AR20: Emtricitabine, tenofovir alafenamide and bictegravir
— J05AR22: Emtricitabine, tenofovir alafenamide, darunavir and cobicistat
HCPCS
No data
Clinical
Clinical Trials
708 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20258212310559374
HivD006678—O98.71612335334145
Hiv-1D015497——2795—22
Acquired immunodeficiency syndromeD000163EFO_0000765B2015123119
InfectionsD007239EFO_0000544——573217
Healthy volunteers/patients———10——5116
Chronic hepatitis bD019694EFO_0004239B18.1—535215
Hepatitis cD006526—B19.2221419
Medication adherenceD055118EFO_0006344—212319
TuberculosisD014376EFO_0000774A15-A19211138
Show 37 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382—U07.1—35—16
Breast feedingD001942————1—12
Sars-cov-2D000086402———12——2
Treatment adherence and complianceD000074822————2——2
Unsafe sexD047568————1——1
Coronavirus infectionsD018352EFO_0007224B34.2——1——1
Metabolic syndromeD024821EFO_0000195E88.810——1——1
Body weight changesD001836————1——1
FastingD005215EFO_0002756———1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gender identityD005783——11——34
Behavior and behavior mechanismsD001520——11——23
Biliary liver cirrhosisD008105—K74.3—1——12
ParasitemiaD018512——11———1
Pulmonary tuberculosisD014397EFO_1000049A15—1———1
Progressive multifocal leukoencephalopathyD007968EFO_0007455A81.2—1———1
Htlv-ii infectionsD015491EFO_1001349——1———1
Amphetamine-related disordersD019969EFO_0004701F15—1———1
Hepatitis b virusD006515———1———1
Patient acceptance of health careD010342———1———1
Show 1 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Insulin resistanceD007333HP_0000855E88.8192————2
Heart disease risk factorsD000082742——1————1
Lipid metabolism disordersD052439——1————1
TransgenesD019076——1————1
Alzheimer diseaseD000544EFO_0000249F031————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD004347——————22
Female genital diseasesD005831EFO_0009549N85————11
Sustained virologic responseD000072230——————11
Bone densityD015519EFO_0003923M85————11
Immune reconstitution inflammatory syndromeD054019—D89.3————11
PsoriasisD011565EFO_0000676L40————11
Contraception behaviorD003268——————11
Hiv seronegativityD018023——————11
Acute kidney injuryD058186HP_0001919N17————11
Bone diseasesD001847—M89.9————11
Show 13 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEmtricitabine
INNemtricitabine
Description
Emtricitabine is an organofluorine compound that is 5-fluorocytosine substituted at the 1 position by a 2-(hydroxymethyl)-1,3-oxathiolan-5-yl group (2R,5S configuration). It is used in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug and a HIV-1 reverse transcriptase inhibitor. It is a pyrimidone, an organofluorine compound, a monothioacetal and a nucleoside analogue.
Classification
Small molecule
Drug classnucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)n([C@@H]2CS[C@H](CO)O2)cc1F
Identifiers
PDB—
CAS-ID143491-57-0
RxCUI—
ChEMBL IDCHEMBL885
ChEBI ID31536
PubChem CID60877
DrugBankDB00879
UNII IDG70B4ETF4S (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Emtriva – Gilead Sciences
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Truvada – Gilead Sciences
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Odefsey – Gilead Sciences
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Biktarvy – Gilead Sciences
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Stribild – Gilead Sciences
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Complera – Gilead Sciences
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Atripla – Gilead Sciences
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Descovy – Gilead Sciences
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Genvoya – Gilead Sciences
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Tabular view
Estimated US medical usage
Emtricitabine
+
Efavirenz
+
Tenofovir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Emtricitabine
Total medical expenditures per year (USD, in millions)
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Emtricitabine
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Rilpivirine
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Tenofovir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Emtricitabine
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Tenofovir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 24,194 documents
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Safety
Black-box Warning
Black-box warning for: Atripla, Atripla access, Biktarvy, Complera, Complera access, Descovy, Efavirenz, emtricitabine and tenofovir disoproxil fumarate, Emtricitabine, Emtricitabine and tenofovir disoproxil fumarate, Emtricitabine/tdf, Emtriva, Genvoya, Odefsey, Stribild, Stribild access, Symtuza, Truvada, Truvada access
Adverse Events
Top Adverse Reactions
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62,506 adverse events reported
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