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AboutPricing
Drug ReportsEmpagliflozin
Jardiance(empagliflozin)
Glyxambi, Jardiance, Synjardy, Trijardy (empagliflozin) is a small molecule pharmaceutical. Empagliflozin was first approved as Jardiance on 2014-05-22. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat chronic renal insufficiency, heart failure, and type 2 diabetes mellitus. The pharmaceutical is active against sodium/glucose cotransporter 2. In addition, it is known to target sodium/glucose cotransporter 1.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Jardiance (discontinued: Empagliflozin)
Combinations
Glyxambi, Synjardy, Trijardy (discontinued: Empagliflozin metformin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Empagliflozin
+
Linagliptin
Tradename
Company
Number
Date
Products
GLYXAMBIBoehringer IngelheimN-206073 RX2015-01-30
2 products, RLD, RS
Empagliflozin
Tradename
Company
Number
Date
Products
JARDIANCEBoehringer IngelheimN-204629 RX2014-08-01
2 products, RLD, RS
Empagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
SYNJARDYBoehringer IngelheimN-206111 RX2015-08-26
4 products, RLD, RS
SYNJARDY XRBoehringer IngelheimN-208658 RX2016-12-09
4 products, RLD, RS
Empagliflozin
+
Linagliptin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
TRIJARDY XRBoehringer IngelheimN-212614 RX2020-01-27
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
glyxambiNew Drug Application2024-06-10
jardianceNew Drug Application2024-12-19
synjardyNew Drug Application2024-10-15
synjardy synjardyNew Drug Application2023-06-26
trijardy xrNew Drug Application2024-06-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
Expiration
Code
EMPAGLIFLOZIN, JARDIANCE, BOEHRINGER INGELHEIM
2025-08-24PED
2025-02-24M-82
2025-02-18PED
2024-08-18I-869
EMPAGLIFLOZIN / LINAGLIPTIN, GLYXAMBI, BOEHRINGER INGELHEIM
2023-03-30M-252
Patent Expiration
Patent
Expires
Flag
FDA Information
Empagliflozin, Jardiance, Boehringer Ingelheim
99499982034-06-11U-2290, U-2731
99499972034-05-17U-2292, U-3199, U-3325, U-3532, U-3533
102586372034-04-03U-2290, U-2731
110903232034-04-03U-3191, U-3192, U-3193
85519572029-10-14U-1651, U-2730
75794492028-08-01DP
77139382027-04-15DS, DP
Empagliflozin / Linagliptin / Metformin Hydrochloride, Trijardy Xr, Boehringer Ingelheim
105961202032-03-07DPU-2775, U-2776, U-2790, U-2792
115648862032-03-07DPU-3531
104061722030-06-15DPU-2733
91557052030-05-21DP
94150162029-04-02DP
100223792029-04-02DPU-2732
Empagliflozin / Metformin Hydrochloride, Synjardy, Boehringer Ingelheim
106104892030-09-30DP
Empagliflozin / Linagliptin, Glyxambi, Boehringer Ingelheim
86739272027-05-04U-1652
91738592027-05-04DPU-1772
110335522027-05-04DP
88838052025-11-26DP
74079552025-05-02DS, DP
81196482023-08-12U-1651, U-1652
81785412023-08-12DPU-1652, U-1653, U-1654
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD19: Linagliptin and empagliflozin
— A10BD20: Metformin and empagliflozin
— A10BD27: Metformin, linagliptin and empagliflozin
— A10BK: Sodium-glucose co-transporter 2 (sglt2) inhibitors
— A10BK03: Empagliflozin
HCPCS
No data
Clinical
Clinical Trials
496 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E1191221102072
Diabetes mellitusD003920HP_0000819E08-E1361025111365
Heart failureD006333HP_0001635I501292317
Kidney diseasesD007674EFO_0003086N08—224311
Chronic renal insufficiencyD051436—N18—22228
Cardiovascular diseasesD002318HP_0001626————325
HypertensionD006973EFO_0000537I10—121—4
Liver diseasesD008107HP_0002910K70-K77—1—2—3
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.81———2—2
Fatty liverD005234EFO_0003934————2—2
Show 11 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10—42——6
ObesityD009765EFO_0001073E66.9—21——3
Insulin resistanceD007333HP_0000855———2——2
Metabolic syndromeD024821EFO_0000195E88.810——2——2
Congenital generalized lipodystrophyD052497HP_0009064———2——2
Lipoatrophic diabetes mellitusD003923EFO_0007346———2——2
Renal insufficiencyD051437HP_0000083N19——1——1
HyperglycemiaD006943HP_0003074R73.9——1——1
Myocardial infarctionD009203EFO_0000612I21——1——1
InfarctionD007238EFO_0009463———1——1
Show 2 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———401———41
Liver failureD017093HP_0001399K72.911———2
NephrolithiasisD053040—N20.0—1———1
Kidney calculiD007669EFO_0004253N20—1———1
Portal hypertensionD006975EFO_0000666K76.6—1———1
Liver cirrhosisD008103EFO_0001422K74.0—1———1
FibrosisD005355———1———1
AscitesD001201HP_0001541R18—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalnutritionD044342EFO_0008572E40-E461————1
Hepatic insufficiencyD048550——1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
KetosisD007662HP_0002919R82.4————22
Urinary tract infectionsD014552EFO_0003103N39.0————11
DehydrationD003681—E86.0————11
HypovolemiaD020896HP_0011106E86————11
Diabetic ketoacidosisD016883EFO_1000897—————11
PancreatitisD010195HP_0001733K85————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEmpagliflozin
INNempagliflozin
Description
Empagliflozin is a C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a sodium-glucose transport protein subtype 2 inhibitor and a hypoglycemic agent. It is a C-glycosyl compound, an aromatic ether, a tetrahydrofuryl ether and a member of monochlorobenzenes.
Classification
Small molecule
Drug classphlorozin derivatives, phenolic glycosides
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(O[C@H]4CCOC4)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
Identifiers
PDB—
CAS-ID864070-44-0
RxCUI—
ChEMBL IDCHEMBL2107830
ChEBI ID82720
PubChem CID11949646
DrugBankDB09038
UNII IDHDC1R2M35U (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ACADS
ACADS
Organism
Homo sapiens
Gene name
ACADS
Gene synonyms
NCBI Gene ID
35
Protein name
short-chain specific acyl-CoA dehydrogenase, mitochondrial
Protein synonyms
acyl-CoA dehydrogenase, C-2 to C-3 short chain, acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, Butyryl-CoA dehydrogenase, epididymis secretory sperm binding protein, mitochondrial short-chain specific acyl-CoA dehydrogenase, unsaturated acyl-CoA reductase
Uniprot ID
P78331
Mouse ortholog
Acads (11409)
short-chain specific acyl-CoA dehydrogenase, mitochondrial (Q91W85)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Jardiance – Eli Lilly
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Estimated US medical usage
Empagliflozin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Empagliflozin
+
Metformin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,221 documents
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Safety
Black-box Warning
Black-box warning for: Synjardy, Synjardy synjardy, Trijardy xr
Adverse Events
Top Adverse Reactions
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37,501 adverse events reported
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