Emadine(emedastine)
Emadine (emedastine) is a small molecule pharmaceutical. Emedastine was first approved as Emadine on 1997-12-29. It is used to treat allergic conjunctivitis in the USA. It has been approved in Europe to treat allergic conjunctivitis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
| immune system diseases | D007154 |
Trade Name
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EMA
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Labels
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic conjunctivitis | EFO_0007141 | D003233 | H10.44 |
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Conjunctivitis | D003231 | HP_0000509 | H10 | — | — | — | 1 | — | 1 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | — | — | 1 | — | 1 |
| Allergic rhinitis | D065631 | — | J30.9 | — | — | — | 1 | — | 1 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | — | — | 1 | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Emedastine |
| INN | emedastine |
| Description | Emedastine is 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis. It has a role as a H1-receptor antagonist, an anti-allergic agent and an antipruritic drug. |
| Classification | Small molecule |
| Drug class | antihistaminics (histamine-H1 receptor antagonists) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOCCn1c(N2CCCN(C)CC2)nc2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 87233-61-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL594 |
| ChEBI ID | 4779 |
| PubChem CID | 3219 |
| DrugBank | DB01084 |
| UNII ID | 9J1H7Y9OJV (ChemIDplus, GSRS) |
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Emedastine
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Additional graphs summarizing 158 documents
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Safety
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23 adverse events reported
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