Eltrombopag
Eltrombopag Olamine, Promacta, Revolade (eltrombopag) is a small molecule pharmaceutical. Eltrombopag was first approved as Promacta on 2008-11-20. It is used to treat aplastic anemia and thrombocytopenic purpura idiopathic in the USA. It has been approved in Europe to treat thrombocytopenic purpura idiopathic. The pharmaceutical is active against thrombopoietin receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alvaiz | New Drug Application | 2024-07-01 |
| eltrombopag | ANDA | 2025-09-03 |
| promacta | New Drug Application | 2025-08-18 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ELTROMBOPAG OLAMINE, PROMACTA, NOVARTIS | |||
| 2025-11-16 | ODE-210 | ||
ELTROMBOPAG OLAMINE, PROMACTA KIT, NOVARTIS | |||
| 2025-11-16 | ODE* | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Eltrombopag Olamine, Promacta, Novartis | |||
| 8052993 | 2027-08-01 | DP | U-930, U-1306, U-1575, U-1714, U-2451 |
| 8052994 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8062665 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8071129 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8828430 | 2027-08-01 | DP | U-1306, U-2451 |
| 7547719 | 2025-07-13 | DS, DP | U-930, U-1306, U-1575, U-1736, U-2451, U-2452 |
HCPCS
No data
Clinical
Clinical Trials
189 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 11 | 42 | 11 | 10 | 18 | 85 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | 8 | 20 | 15 | 10 | 19 | 70 |
| Purpura | D011693 | HP_0000979 | D69.2 | 5 | 8 | 8 | 2 | 8 | 31 |
| Thrombocytopenic purpura | D011696 | — | — | 4 | 8 | 8 | 2 | 7 | 29 |
| Aplastic anemia | D000741 | — | D61.9 | 2 | 15 | 4 | 2 | 5 | 25 |
| Healthy volunteers/patients | — | — | — | 3 | — | 1 | 1 | — | 5 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | 1 | 1 | 1 | 4 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 3 | 17 | 2 | — | 3 | 21 |
| Leukemia | D007938 | — | C95 | 5 | 15 | 2 | — | — | 17 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 11 | 1 | — | 1 | 16 |
| Preleukemia | D011289 | — | — | 3 | 10 | 1 | — | — | 14 |
| Syndrome | D013577 | — | — | 3 | 9 | 1 | — | — | 13 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 9 | 1 | — | — | 11 |
| Hepatitis c | D006526 | — | B19.2 | 1 | 3 | 6 | — | 2 | 11 |
| Myeloid leukemia | D007951 | — | C92 | 4 | 8 | 2 | — | — | 10 |
| Hepatitis | D006505 | — | K75.9 | — | 3 | 5 | — | 1 | 8 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 3 | 5 | — | — | 7 |
Show 21 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | — | 3 | — | — | 1 | 4 |
| Pancytopenia | D010198 | — | D61.81 | 1 | 3 | — | — | — | 3 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 3 | — | — | — | 3 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | 1 | — | — | 1 | 2 |
| Wiskott-aldrich syndrome | D014923 | EFO_0003903 | D82.0 | — | 2 | — | — | — | 2 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.03 | — | 2 | — | — | — | 2 |
| Fanconi syndrome | D005198 | — | — | — | 2 | — | — | — | 2 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 1 | 1 | — | — | — | 2 |
| Monocytic leukemia acute | D007948 | — | — | 1 | 1 | — | — | — | 2 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 1 | 1 | — | — | — | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 2 | — | — | — | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | — | — | — | — | 1 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Connective and soft tissue neoplasms | D018204 | — | — | 1 | — | — | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | 1 | — | — | — | — | 1 |
| Acute radiation syndrome | D054508 | — | — | 1 | — | — | — | — | 1 |
| Photosensitivity disorders | D010787 | — | L57.1 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Splenectomy | D013156 | — | — | — | — | — | — | 1 | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
| Immune system diseases | D007154 | — | D89.9 | — | — | — | — | 1 | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 1 | 1 |
| Hemorrhagic disorders | D006474 | — | D69.9 | — | — | — | — | 1 | 1 |
| Skin manifestations | D012877 | — | — | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | — | — | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Bone marrow diseases | D001855 | — | — | — | — | — | — | 1 | 1 |
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Eltrombopag |
| INN | eltrombopag |
| Description | Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Eltrombopag is sold under the brand name Revolade outside the US and is marketed by Novartis. It is a thrombopoietin receptor agonist. It is taken by mouth.
|
| Classification | Small molecule |
| Drug class | thrombopoetin agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O |
Identifiers
| PDB | — |
| CAS-ID | 496775-61-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL461101 |
| ChEBI ID | 85010 |
| PubChem CID | 9846180 |
| DrugBank | DB06210 |
| UNII ID | S56D65XJ9G (ChemIDplus, GSRS) |
Target
Agency Approved
MPL
MPL
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Promacta – Ligand Pharmaceuticals
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Promacta – Novartis
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 3,372 documents
View more details
Safety
Black-box Warning
Black-box warning for: Alvaiz, Eltrombopag, Promacta
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
23,002 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use