Alvaiz, Revolade(eltrombopag)
Eltrombopag Olamine, Promacta, Revolade (eltrombopag) is a small molecule pharmaceutical. Eltrombopag was first approved as Promacta on 2008-11-20. It is used to treat aplastic anemia and thrombocytopenic purpura idiopathic in the USA. It has been approved in Europe to treat thrombocytopenic purpura idiopathic. The pharmaceutical is active against thrombopoietin receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Alvaiz
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| thrombocytopenic purpura idiopathic | EFO_0007160 | D016553 | D69.3 |
| aplastic anemia | HP_0001915 | D000741 | D61.9 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ELTROMBOPAG OLAMINE, PROMACTA, NOVARTIS | |||
| 2025-11-16 | ODE-210 | ||
ELTROMBOPAG OLAMINE, PROMACTA KIT, NOVARTIS | |||
| 2025-11-16 | ODE* | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Eltrombopag Olamine, Promacta, Novartis | |||
| 8052993 | 2027-08-01 | DP | U-930, U-1306, U-1575, U-1714, U-2451 |
| 8052994 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8062665 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8071129 | 2027-08-01 | DP | U-930, U-1306, U-1714, U-2451 |
| 8828430 | 2027-08-01 | DP | U-1306, U-2451 |
| 7547719 | 2025-07-13 | DS, DP | U-930, U-1306, U-1575, U-1736, U-2451, U-2452 |
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Clinical
Clinical Trials
177 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 11 | 41 | 13 | 10 | 16 | 84 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | 8 | 20 | 15 | 9 | 17 | 67 |
| Thrombocytopenic purpura | D011696 | — | — | 6 | 8 | 11 | 3 | 7 | 35 |
| Purpura | D011693 | HP_0000979 | D69.2 | 6 | 8 | 11 | 3 | 7 | 35 |
| Anemia | D000740 | HP_0001903 | D64.9 | 3 | 19 | 3 | 1 | 3 | 25 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 2 | 15 | 4 | 2 | 3 | 23 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | 1 | 1 | — | 3 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 15 | 2 | — | — | 17 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 11 | 1 | — | — | 15 |
| Preleukemia | D011289 | — | — | 3 | 10 | 1 | — | — | 14 |
| Syndrome | D013577 | — | — | 3 | 9 | 1 | — | — | 13 |
| Hepatitis c | D006526 | — | B19.2 | 1 | 3 | 6 | — | 2 | 11 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 8 | 1 | — | — | 10 |
| Myeloid leukemia | D007951 | — | C92 | 4 | 8 | 2 | — | — | 10 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | 3 | 5 | — | 1 | 8 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 3 | 5 | — | — | 7 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 3 | 3 | — | — | 5 |
Show 20 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | — | 3 | — | — | — | 3 |
| Pancytopenia | D010198 | HP_0001876 | D61.81 | 1 | 3 | — | — | — | 3 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 3 | — | — | — | 3 |
| Wiskott-aldrich syndrome | D014923 | EFO_0003903 | D82.0 | — | 2 | — | — | — | 2 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | — | 2 | — | — | — | 2 |
| Fanconi syndrome | D005198 | — | — | — | 2 | — | — | — | 2 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 1 | 1 | — | — | — | 2 |
| Monocytic leukemia acute | D007948 | — | — | 1 | 1 | — | — | — | 2 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 1 | 1 | — | — | — | 2 |
| Basophilic leukemia acute | D015471 | — | C94.8 | 1 | 1 | — | — | — | 2 |
Show 27 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Connective and soft tissue neoplasms | D018204 | — | — | 1 | — | — | — | — | 1 |
| Radiation injuries | D011832 | — | — | 1 | — | — | — | — | 1 |
| Acute radiation syndrome | D054508 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Splenectomy | D013156 | — | — | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | HP_0001907 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Eltrombopag |
| INN | eltrombopag |
| Description | Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Eltrombopag is sold under the brand name Revolade outside the US and is marketed by Novartis. It is a thrombopoietin receptor agonist. It is taken by mouth.
|
| Classification | Small molecule |
| Drug class | thrombopoetin agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O |
Identifiers
| PDB | — |
| CAS-ID | 496775-61-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL461101 |
| ChEBI ID | 85010 |
| PubChem CID | 9846180 |
| DrugBank | DB06210 |
| UNII ID | S56D65XJ9G (ChemIDplus, GSRS) |
Target
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MPL
MPL
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Promacta – Ligand Pharmaceuticals
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Promacta – Novartis
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Safety
Black-box Warning
Black-box warning for: Alvaiz, Promacta
Adverse Events
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21,071 adverse events reported
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