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Drug ReportsEltrombopag
Alvaiz, Revolade(eltrombopag)
Eltrombopag Olamine, Promacta, Revolade (eltrombopag) is a small molecule pharmaceutical. Eltrombopag was first approved as Promacta on 2008-11-20. It is used to treat aplastic anemia and thrombocytopenic purpura idiopathic in the USA. It has been approved in Europe to treat thrombocytopenic purpura idiopathic. The pharmaceutical is active against thrombopoietin receptor.
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Events Timeline
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YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Alvaiz
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Eltrombopag choline
Tradename
Company
Number
Date
Products
ALVAIZTevaN-216774 RX2023-11-29
4 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
alvaizNew Drug Application2024-07-01
promactaNew Drug Application2025-01-03
Agency Specific
FDA
EMA
Expiration
Code
ELTROMBOPAG OLAMINE, PROMACTA, NOVARTIS
2025-11-16ODE-210
ELTROMBOPAG OLAMINE, PROMACTA KIT, NOVARTIS
2025-11-16ODE*
Patent Expiration
Patent
Expires
Flag
FDA Information
Eltrombopag Olamine, Promacta, Novartis
80529932027-08-01DPU-930, U-1306, U-1575, U-1714, U-2451
80529942027-08-01DPU-930, U-1306, U-1714, U-2451
80626652027-08-01DPU-930, U-1306, U-1714, U-2451
80711292027-08-01DPU-930, U-1306, U-1714, U-2451
88284302027-08-01DPU-1306, U-2451
75477192025-07-13DS, DPU-930, U-1306, U-1575, U-1736, U-2451, U-2452
ATC Codes
B: Blood and blood forming organ drugs
B02: Antihemorrhagics
B02B: Vitamin k and other hemostatics
B02BX: Other systemic hemostatics in atc
B02BX05: Eltrombopag
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameEltrombopag
INNeltrombopag
Description
Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Eltrombopag is sold under the brand name Revolade outside the US and is marketed by Novartis. It is a thrombopoietin receptor agonist. It is taken by mouth.
Classification
Small molecule
Drug classthrombopoetin agonists
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O
Identifiers
PDB
CAS-ID496775-61-2
RxCUI
ChEMBL IDCHEMBL461101
ChEBI ID85010
PubChem CID9846180
DrugBankDB06210
UNII IDS56D65XJ9G (ChemIDplus, GSRS)
Target
Agency Approved
MPL
MPL
Organism
Homo sapiens
Gene name
MPL
Gene synonyms
TPOR
NCBI Gene ID
Protein name
thrombopoietin receptor
Protein synonyms
CD110, Myeloproliferative leukemia protein, myeloproliferative leukemia virus oncogene, Proto-oncogene c-Mpl, TPO-R
Uniprot ID
Mouse ortholog
Mpl (17480)
thrombopoietin receptor (Q8BRX0)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
£
Promacta Ligand Pharmaceuticals
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Promacta Novartis
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Estimated US medical usage
No data
Trends
No data
Safety
Black-box Warning
Black-box warning for: Alvaiz, Promacta
Adverse Events
0 adverse events reported
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