Elafibranor
Iqirvo (elafibranor) is a small molecule pharmaceutical. Elafibranor was first approved as Iqirvo on 2024-06-10. It is known to target peroxisome proliferator-activated receptor alpha and peroxisome proliferator-activated receptor gamma.
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FDA approval date
EMA approval date
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Study first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Iqirvo
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| iqirvo | New Drug Application | 2024-06-10 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Biliary liver cirrhosis | D008105 | — | K74.3 | — | 1 | 4 | — | 1 | 6 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 3 | 1 | — | — | 4 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 3 | 1 | — | — | 4 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | 1 | — | — | 2 |
| Fibrosis | D005355 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 3 | — | — | — | 4 |
| Abdominal obesity | D056128 | — | — | — | 3 | — | — | — | 3 |
| Alcoholic fatty liver | D005235 | — | K70.0 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | — | — | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | — | — | — | 2 |
| Dyslipidemias | D050171 | — | — | 1 | 1 | — | — | — | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | — | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | — | 1 |
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Geriatric psychiatry | D005852 | — | — | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | — | — | — | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Elafibranor |
| INN | elafibranor |
| Description | Elafibranor (INN, code name GFT505) is an experimental medication that is being studied and developed by Genfit for the treatment of cardiometabolic diseases including diabetes, insulin resistance, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD).
|
| Classification | Small molecule |
| Drug class | Antihyperlipidemic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSc1ccc(C(=O)/C=C/c2cc(C)c(OC(C)(C)C(=O)O)c(C)c2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 824932-88-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707395 |
| ChEBI ID | — |
| PubChem CID | 9864881 |
| DrugBank | DB05187 |
| UNII ID | 2J3H5C81A5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PPARA
PPARA
Organism
Homo sapiens
Gene name
PPARA
Gene synonyms
NR1C1, PPAR
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor alpha
Protein synonyms
Nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha
Uniprot ID
Mouse ortholog
Ppara (19013)
peroxisome proliferator-activated receptor alpha (P23204)
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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274 adverse events reported
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