Edrecolomab
Edrecolomab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target epithelial cell adhesion molecule.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| choline c 11 | New Drug Application | 2024-01-10 |
| zyrexal | unapproved drug other | 2020-02-10 |
Indications
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Agency Specific
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Clinical
Clinical Trials
710 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Angioedema | D000799 | EFO_0005532 | T78.3 | 6 | 21 | 25 | 4 | 14 | 62 |
| Hereditary angioedemas | D054179 | EFO_0004131 | — | 7 | 22 | 22 | 5 | 13 | 61 |
| Lymphoma | D008223 | — | C85.9 | 17 | 24 | 4 | 1 | 2 | 40 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 11 | 16 | 2 | 1 | 5 | 32 |
| Leukemia | D007938 | — | C95 | 9 | 12 | 2 | 1 | — | 20 |
| Covid-19 | D000086382 | — | — | 3 | 10 | 3 | 2 | 4 | 18 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 6 | 2 | — | 2 | 2 | 11 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 5 | 5 | 1 | 1 | — | 10 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 5 | 2 | 1 | 1 | 10 |
| Hereditary angioedema types i and ii | D056829 | — | — | 2 | 5 | 3 | 1 | 1 | 10 |
Show 43 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 32 | 17 | 4 | — | 5 | 51 |
| Carcinoma | D002277 | — | C80.0 | 6 | 9 | 1 | — | 4 | 17 |
| Colorectal neoplasms | D015179 | — | — | 7 | 7 | 1 | — | 3 | 16 |
| Multiple myeloma | D009101 | — | C90.0 | 8 | 7 | 2 | — | 2 | 15 |
| Plasma cell neoplasms | D054219 | — | — | 8 | 5 | 2 | — | 2 | 13 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 6 | 6 | 1 | — | 2 | 12 |
| Prostatic neoplasms | D011471 | — | C61 | 6 | 4 | 1 | — | 1 | 11 |
| Wounds and injuries | D014947 | — | T14.8 | — | 3 | 1 | — | 7 | 11 |
| B-cell lymphoma | D016393 | — | — | 6 | 5 | 2 | — | 1 | 10 |
| Niemann-pick diseases | D009542 | — | E75.24 | 6 | 6 | 4 | — | — | 10 |
Show 85 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 38 | 3 | — | — | 3 | 41 |
| Malaria | D008288 | EFO_0001068 | B54 | 21 | 3 | — | — | — | 21 |
| Non-small-cell lung carcinoma | D002289 | — | — | 11 | 10 | — | — | 2 | 19 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 7 | — | — | 5 | 13 |
| Melanoma | D008545 | — | — | 8 | 5 | — | — | 2 | 11 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 3 | 3 | — | — | 5 | 11 |
| Headache | D006261 | HP_0002315 | R51 | — | 1 | — | — | 10 | 11 |
| Triple negative breast neoplasms | D064726 | — | — | 6 | 5 | — | — | — | 10 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 5 | 4 | — | — | 2 | 10 |
| Urinary bladder neoplasms | D001749 | — | C67 | 6 | 3 | — | — | 2 | 9 |
Show 126 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatty liver | D005234 | EFO_0003934 | — | 2 | — | — | — | 2 | 4 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 2 | — | — | — | 1 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | — | — | — | 1 | 3 |
| Cutaneous malignant melanoma | D000096142 | — | — | 1 | — | — | — | 1 | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 2 | — | — | — | — | 2 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | — | — | — | 1 | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 1 | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | 1 | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 1 | 2 |
Show 39 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neck pain | D019547 | HP_0030833 | M54.2 | — | — | — | — | 14 | 14 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 9 | 9 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 7 | 7 |
| Impacted tooth | D014095 | HP_0011079 | K01.1 | — | — | — | — | 7 | 7 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 4 | 4 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 4 | 4 |
| Circulating neoplastic cells | D009360 | — | — | — | — | — | — | 3 | 3 |
| Musculoskeletal manipulations | D026201 | — | — | — | — | — | — | 3 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 3 | 3 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 3 | 3 |
Show 195 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edrecolomab |
| INN | edrecolomab |
| Description | Edrecolomab (mouse mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108955 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB13375 |
| UNII ID | 0KYI9U9FSJ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
EPCAM
EPCAM
Organism
Homo sapiens
Gene name
EPCAM
Gene synonyms
GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
NCBI Gene ID
Protein name
epithelial cell adhesion molecule
Protein synonyms
Adenocarcinoma-associated antigen, CD326, Cell surface glycoprotein Trop-1, EGP, EGP314, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, hEGP314, human epithelial glycoprotein-2, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, membrane component, chromosome 4, surface marker (35kD glycoprotein), trophoblast cell surface antigen 1, Tumor-associated calcium signal transducer 1
Uniprot ID
Mouse ortholog
Epcam (17075)
epithelial cell adhesion molecule (Q99JW5)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,044 adverse events reported
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