Edotreotide
Gallium Ga Edotreotide, SomaKit TOC (edotreotide) is a small molecule pharmaceutical. Edotreotide was first approved as Somakit toc on 2016-12-08. It has been approved in Europe to treat neuroendocrine tumors and radionuclide imaging. It is known to target somatostatin receptor type 2.
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ga-68-dotatoc | New Drug Application | 2021-12-08 |
Indications
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
GALLIUM GA-68 EDOTREOTIDE, GALLIUM GA 68 EDOTREOTIDE, UIHC PET IMAGING | |||
| 2026-08-21 | ODE-383, W | ||
| 2024-08-21 | NCE, W | ||
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Clinical
Clinical Trials
62 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 10 | 18 | 6 | — | 14 | 44 |
| Neoplasms | D009369 | — | C80 | 7 | 3 | 1 | — | 1 | 11 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | 1 | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 1 | 1 | — | — | 3 |
| Pituitary neoplasms | D010911 | — | — | — | — | 1 | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | 1 | — | 1 | 2 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | 1 | — | — | 1 |
| Thymoma | D013945 | — | — | — | — | 1 | — | — | 1 |
| Thymus neoplasms | D013953 | — | C37 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoid tumor | D002276 | — | D3A.00 | 5 | 6 | — | — | 3 | 12 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 3 | 7 | — | — | 2 | 10 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 2 | 3 | — | — | 3 | 8 |
| Medulloblastoma | D008527 | — | — | 1 | 5 | — | — | 2 | 7 |
| Paraganglioma | D010235 | — | — | 2 | 4 | — | — | 2 | 6 |
| Pheochromocytoma | D010673 | — | — | 2 | 3 | — | — | 1 | 5 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | 2 | 1 | — | — | 1 | 4 |
| Lymphoma | D008223 | — | C85.9 | 2 | 1 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | 1 | 2 |
| Merkel cell carcinoma | D015266 | EFO_1001471 | C4A | — | 1 | — | — | 1 | 2 |
Show 12 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | 3 | — | — | — | — | 3 |
| Endocrine gland neoplasms | D004701 | EFO_0003769 | D35 | 1 | — | — | — | 1 | 2 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 2 | — | — | — | — | 2 |
| Nervous system neoplasms | D009423 | — | — | 2 | — | — | — | — | 2 |
| Malignant carcinoid syndrome | D008303 | — | E34.0 | 2 | — | — | — | — | 2 |
| Von hippel-lindau disease | D006623 | — | Q85.83 | 1 | — | — | — | — | 1 |
| Multiple endocrine neoplasia type 1 | D018761 | — | E31.21 | 1 | — | — | — | — | 1 |
| Multiple endocrine neoplasia | D009377 | — | E31.2 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 3 | 3 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | — | 2 | 2 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 2 | 2 |
| Intestinal neoplasms | D007414 | — | C26.0 | — | — | — | — | 2 | 2 |
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | — | — | — | 1 | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | — | — | 1 | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | — | — | — | 1 | 1 |
| Ganglioneuroma | D005729 | — | — | — | — | — | — | 1 | 1 |
| Brain stem neoplasms | D020295 | EFO_1001767 | — | — | — | — | — | 1 | 1 |
| Adenoma | D000236 | — | — | — | — | — | — | 1 | 1 |
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edotreotide |
| INN | edotreotide |
| Description | Edotreotide (USAN, also known as (DOTA0-Phe1-Tyr3) octreotide, DOTA-TOC, DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer. When used therapeutically it is an example of peptide receptor radionuclide therapy.
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| Classification | Small molecule |
| Drug class | peptides: inhibition of growth hormone release |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 173606-11-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL408350 |
| ChEBI ID | — |
| PubChem CID | 158782 |
| DrugBank | DB15494 |
| UNII ID | U194AS08HZ (ChemIDplus, GSRS) |
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13 adverse events reported
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